biostudies-literatureRusso ARegion of Campania, Italy973https://www.ebi.ac.uk/biostudies/studies/S-EPMC10459783biostudies-literatureUnknown12(8)<h4>Introduction</h4>Acute kidney disease and chronic kidney disease are considered conditions that can increase the mortality and severity of COVID-19. However, few studies have investigated the impact of creatinine levels on COVID-19 progression in patients without a history of chronic kidney disease. The aim of the study was to assess the impact of creatinine levels at hospital admission on COVID-19 progression and mortality.<h4>Methods</h4>We performed a multicenter, observational, retrospective study involving seventeen COVID-19 Units in the Campania region in southern Italy. All adult (≥18 years) patients, hospitalized with a diagnosis of SARS-CoV-2 infection confirmed by a positive reverse transcriptase-polymerase chain reaction on a naso-oropharyngeal swab, from 28 February 2020 toPathogens (Basel, Switzerland)Prognostic Value of Creatinine Levels at Admission on Disease Progression and Mortality in Patients with COVID-19-An Observational Retrospective Study.PMC10459783DGR no. 140 of 17 March 2020; DGR n. 504 of 10.11.2021Monari CPonticiello ARusso GMaggi PMasullo AEsposito VAllegorico EGambardella MGentile IOnorato LSangiovanni VPisaturo MCiminelli FDell'Aquila GParrella RCoppola NCalabria GManzillo ECoviCamp GroupRusso ACarriero CGentile VPisapia RfalsePrognostic Value of Creatinine Levels at Admission on Disease Progression and Mortality in Patients with COVID-19-An Observational Retrospective Study.<h4>Introduction</h4>Acute kidney disease and chronic kidney disease are considered conditions that can increase the mortality and severity of COVID-19. However, few studies have investigated the impact of creatinine levels on COVID-19 progression in patients without a history of chronic kidney disease. The aim of the study was to assess the impact of creatinine levels at hospital admission on COVID-19 progression and mortality.<h4>Methods</h4>We performed a multicenter, observational, retrospective study involving seventeen COVID-19 Units in the Campania region in southern Italy. All adult (≥18 years) patients, hospitalized with a diagnosis of SARS-CoV-2 infection confirmed by a positive reverse transcriptase-polymerase chain reaction on a naso-oropharyngeal swab, from 28 February 2020 to2023-01-01T00:00:00Z2023 Jul2025-04-26T20:26:57.829Z2024-11-13T13:34:40.334ZS-EPMC104597833762393310.3390/pathogens12080973