biostudies-literatureSideli LNational Institute of Mental Health of the National Institutes of Health (Project FEP-CAUSAL)São Paulo Research FoundationCIBERSAM, Madrid Regional GovernmentEuropean Union Structural Funds, European Union Seventh Framework Program, European Union H2020 Program under the Innovative Medicines Initiative 2 Joint Undertaking: Project PRISM-2Project AIMS-2-TRIALSEuropean Union - NextGenerationEUHorizon Europe, the National Institute of Mental Health of the National Institutes of Health (Project ProNET)European Community's Seventh Framework Programme, (Project EU-GEI)Medical Research Council fellowshipNetherlands Scientific OrganizationEconomic and Social Research Council (ESRC) Centre for Society and Mental Health at King's College LondonMedical Research Council Clinical Academic Research Partnership1573-1580https://www.ebi.ac.uk/biostudies/studies/S-EPMC10460355biostudies-literatureUnknown58(10)This study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS did not attenuate the association between childhood maltreatment and IQ in cases or controls. Findings suggest that these expressions of genetic liability cannot account for the lower levels of cognition found among adults maltreated in childhood.Social psychiatry and psychiatric epidemiologyThe relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case-control study.PMC10460355Award Number 1U01MH124639-01HEALTH-F2-2010-241909Award Number 5P50MH115846-03101034377#MR/WO27720/1VIDI award no. 91.718.336PMP21/00051, PI19/010242012/0417-0ES/S012567/1MR/W030608/1777394B2017/BMD-3740 AGES-CM-2Lorente-Rovira EGayer-Anderson CDi Forti MMezquida Gvan Dam DMurray RMBeards SArrojo MMenezes PRAndreu-Bernabeu Ade Haan LMarrazzo GFerchiou ASanchez-Gutierrez TTronche AMTosato SLlorca PMJamain SRuggeri MBaudin GDuran-Cutilla Mvan der Ven ERichard JRLeboyer MRapado-Castro MFerraro LHubbard KFontana AMarcelino Loureiro CCarracedo AAlameda LBentall RTermorshuizen FLa Barbera DLlorente CRodriguez Solano JJBerardi DBobes JSideli LTripoli GSelten JPM Diaz-Caneja CSaiz PAVelthorst ERutten BPFrijda FShuhama RDel-Ben CMTrotta GLasalvia AArango CTortelli ANacher JMoreno CCabrera BTarricone ISeminerio FKirkbride JBBonetto CParellada MSanjuan JGonzalez Penas JSchurhoff FPignon BCuadrado PVan Os JJimenez-Lopez EGarcia-Portilla PBernardo MLopez Montoya GMesschaart ECostas JCharpeaud TMolto MDAas MD'Andrea GAmoretti SFraguas DSartorio CBonora EMatteis MSchimmenti AFisher HLLa Cascia CJongsma HEMorgan CStilo SSeri MCristofalo DEU-GEI WP2 GroupSanchez ESantos JLJones PBMuratori RQuattrone DFranke NfalseThe relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case-control study.This study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS did not attenuate the association between childhood maltreatment and IQ in cases or controls. Findings suggest that these expressions of genetic liability cannot account for the lower levels of cognition found among adults maltreated in childhood.2023-01-01T00:00:00Z2023 Oct2025-04-05T00:08:36.19Z2025-04-05T00:08:36.19ZS-EPMC104603553733532010.1007/s00127-023-02513-0