{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kim JW"],"funding":["National Research Foundation of Korea (NRF)","National Research Foundation of Korea"],"pagination":["567"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10460413"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(8)"],"pubmed_abstract":["Ferroptosis, a type of cell death induced by lipid peroxidation, has emerged as a novel anti-cancer strategy. Cancer cells frequently acquire resistance to ferroptosis. However, the underlying mechanisms are poorly understood. To address this issue, we conducted a thorough investigation of the genomic and transcriptomic data derived from hundreds of human cancer cell lines and primary tissue samples, with a particular focus on non-small cell lung carcinoma (NSCLC). It was observed that mutations in Kelch-like ECH-associated protein 1 (KEAP1) and subsequent nuclear factor erythroid 2-related factor 2 (NRF2, also known as NFE2L2) activation are strongly associated with ferroptosis resistance in NSCLC. Additionally, AIFM2 gene, which encodes ferroptosis suppressor protein 1 (FSP1), was identi"],"journal":["Cell death & disease"],"pubmed_title":["FSP1 confers ferroptosis resistance in KEAP1 mutant non-small cell lung carcinoma in NRF2-dependent and -independent manner."],"pmcid":["PMC10460413"],"funding_grant_id":["2021R1C1C1003988","2022R1A2C4002108"],"pubmed_authors":["Kim H","Bae SH","Lee SC","Lee H","Kim JW","Lee EW","Lee JY","Oh KJ","Kim S","Kim WK","Bae KH","Ban HS","Han TH","Han BS","Kim MJ"],"additional_accession":[]},"is_claimable":false,"name":"FSP1 confers ferroptosis resistance in KEAP1 mutant non-small cell lung carcinoma in NRF2-dependent and -independent manner.","description":"Ferroptosis, a type of cell death induced by lipid peroxidation, has emerged as a novel anti-cancer strategy. Cancer cells frequently acquire resistance to ferroptosis. However, the underlying mechanisms are poorly understood. To address this issue, we conducted a thorough investigation of the genomic and transcriptomic data derived from hundreds of human cancer cell lines and primary tissue samples, with a particular focus on non-small cell lung carcinoma (NSCLC). It was observed that mutations in Kelch-like ECH-associated protein 1 (KEAP1) and subsequent nuclear factor erythroid 2-related factor 2 (NRF2, also known as NFE2L2) activation are strongly associated with ferroptosis resistance in NSCLC. Additionally, AIFM2 gene, which encodes ferroptosis suppressor protein 1 (FSP1), was identi","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2025-04-04T10:10:04.043Z","creation":"2025-04-04T10:10:04.043Z"},"accession":"S-EPMC10460413","cross_references":{"pubmed":["37633973"],"doi":["10.1038/s41419-023-06070-x"]}}