{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rapp TL"],"funding":["U.S. Department of Health &amp; Human Services | NIH | National Institute of General Medical Sciences","Washington Research Foundation","NIGMS NIH HHS","National Science Foundation"],"pagination":["5250"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10462736"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["Photodynamic hydrogel biomaterials have demonstrated great potential for user-triggered therapeutic release, patterned organoid development, and four-dimensional control over advanced cell fates in vitro. Current photosensitive materials are constrained by their reliance on high-energy ultraviolet light (<400 nm) that offers poor tissue penetrance and limits access to the broader visible spectrum. Here, we report a family of three photolabile material crosslinkers that respond rapidly and with unique tricolor wavelength-selectivity to low-energy visible light (400-617 nm). We show that when mixed with multifunctional poly(ethylene glycol) macromolecular precursors, ruthenium polypyridyl- and ortho-nitrobenzyl (oNB)-based crosslinkers yield cytocompatible biomaterials that can undergo spati"],"journal":["Nature communications"],"pubmed_title":["Tricolor visible wavelength-selective photodegradable hydrogel biomaterials."],"pmcid":["PMC10462736"],"funding_grant_id":["R35GM138036","N/A","DMR 1652141","DMR 1807398","R35 GM138036"],"pubmed_authors":["Rapp TL","DeForest CA"],"additional_accession":[]},"is_claimable":false,"name":"Tricolor visible wavelength-selective photodegradable hydrogel biomaterials.","description":"Photodynamic hydrogel biomaterials have demonstrated great potential for user-triggered therapeutic release, patterned organoid development, and four-dimensional control over advanced cell fates in vitro. Current photosensitive materials are constrained by their reliance on high-energy ultraviolet light (<400 nm) that offers poor tissue penetrance and limits access to the broader visible spectrum. Here, we report a family of three photolabile material crosslinkers that respond rapidly and with unique tricolor wavelength-selectivity to low-energy visible light (400-617 nm). We show that when mixed with multifunctional poly(ethylene glycol) macromolecular precursors, ruthenium polypyridyl- and ortho-nitrobenzyl (oNB)-based crosslinkers yield cytocompatible biomaterials that can undergo spati","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2026-06-04T06:50:37.735Z","creation":"2025-04-06T14:39:17.796Z"},"accession":"S-EPMC10462736","cross_references":{"pubmed":["37640707"],"doi":["10.1038/s41467-023-40805-w"]}}