biostudies-literatureUnknown24(1)La Scala E<h4>Background</h4>Treatment of chronic total occlusion (CTO) by percutaneous coronary intervention (PCI) is associated with the difficulty of guidewire manipulation through the occluded segment, particularly when there is hard tissue due to calcification. The purpose of this randomised controlled trial is to determine whether improved planning of CTO-PCI using coronary computed tomographic angiography (CCTA) (versus conventional angiography) increases success rates of wire crossing in ≤ 60 min in difficult cases.<h4>Methods</h4>This is a randomised controlled open-label multi-centre trial in a superiority framework with 1:1 allocation ratio. Participants (n = 130) will be randomised into two groups: the study group who will receive standard of care with the addition of preoperative coronaTrials560https://www.ebi.ac.uk/biostudies/studies/S-EPMC10463280biostudies-literatureEffect of preoperative coronary CT for planning of percutaneous coronary intervention for complex chronic total occlusion (CTS-C-CTOPCI): study protocol for an open-label randomised controlled trial.PMC10463280Boge ACT-CTO PCI Study GroupAndreini DSaffarini MGalassi AMuller JHGrancini LVadala GPeyre JPReSurgMaupas EBrunet JLa Scala EfalseEffect of preoperative coronary CT for planning of percutaneous coronary intervention for complex chronic total occlusion (CTS-C-CTOPCI): study protocol for an open-label randomised controlled trial.<h4>Background</h4>Treatment of chronic total occlusion (CTO) by percutaneous coronary intervention (PCI) is associated with the difficulty of guidewire manipulation through the occluded segment, particularly when there is hard tissue due to calcification. The purpose of this randomised controlled trial is to determine whether improved planning of CTO-PCI using coronary computed tomographic angiography (CCTA) (versus conventional angiography) increases success rates of wire crossing in ≤ 60 min in difficult cases.<h4>Methods</h4>This is a randomised controlled open-label multi-centre trial in a superiority framework with 1:1 allocation ratio. Participants (n = 130) will be randomised into two groups: the study group who will receive standard of care with the addition of preoperative corona2023-01-01T00:00:00Z2023 Aug2025-04-19T10:14:38.415Z2024-11-15T11:28:14.043ZS-EPMC104632803764457310.1186/s13063-023-07458-y