{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ighodaro ET"],"funding":["NIH/NIA","NIA NIH HHS","NINDS NIH HHS"],"pagination":["138"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10464008"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(1)"],"pubmed_abstract":["Cerebrovascular pathologies other than frank infarctions are commonly seen in aged brains. Here, we focus on multi-lumen vascular profiles (MVPs), which are characterized by multiple vessel lumens enclosed in a single vascular channel. Little information exists on the prevalence, risk factors, and co-pathologies of MVPs. Therefore, we used samples and data from the University of Kentucky Alzheimer's Disease Research Center (n = 91), the University of Kentucky Pathology Department (n = 31), and the University of Pittsburgh Pathology Department (n = 4) to study MVPs. Age at death was correlated with MVP density in the frontal neocortex, Brodmann Area 9 (r = 0.51; p < 0.0001). Exploratory analyses were performed to evaluate the association between conventional vascular risk factors (e.g., hyp"],"journal":["Acta neuropathologica communications"],"pubmed_title":["A neuropathologic feature of brain aging: multi-lumen vascular profiles."],"pmcid":["PMC10464008"],"funding_grant_id":["P30 AG028383","T32 AG078110","This work was supported by the following National Institute of Health grants: F30 NS090714-01A1; P30 AG028383","P30 AG066468","R01 AG042419","T32 AG000242","R21AG066865","F30 NS090714","K25 AG043546","R21 AG066865","P30 AG072946","R01 AG038651"],"pubmed_authors":["Jicha GA","Wilcock DM","Neltner JH","Abner EL","Schmitt FA","Shahidehpour RK","Shih AY","Ighodaro ET","Kryscio RJ","Bachstetter AD","Grant RI","Nelson RS","Fardo DW","Nelson PT","Van Eldik LJ"],"additional_accession":[]},"is_claimable":false,"name":"A neuropathologic feature of brain aging: multi-lumen vascular profiles.","description":"Cerebrovascular pathologies other than frank infarctions are commonly seen in aged brains. Here, we focus on multi-lumen vascular profiles (MVPs), which are characterized by multiple vessel lumens enclosed in a single vascular channel. Little information exists on the prevalence, risk factors, and co-pathologies of MVPs. Therefore, we used samples and data from the University of Kentucky Alzheimer's Disease Research Center (n = 91), the University of Kentucky Pathology Department (n = 31), and the University of Pittsburgh Pathology Department (n = 4) to study MVPs. Age at death was correlated with MVP density in the frontal neocortex, Brodmann Area 9 (r = 0.51; p < 0.0001). Exploratory analyses were performed to evaluate the association between conventional vascular risk factors (e.g., hyp","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2026-07-14T22:59:43.626Z","creation":"2025-04-06T14:37:43.378Z"},"accession":"S-EPMC10464008","cross_references":{"pubmed":["37641147"],"doi":["10.1186/s40478-023-01638-2"]}}