biostudies-literatureDi SXingang Cui, Xiuwu Pan, Sishun Gan, Jian Chu, Qiwei YangXingang Cui, Xiuwu Pan, Sishun Gan, Jian Chu, Qiwei Yang186https://www.ebi.ac.uk/biostudies/studies/S-EPMC10468907biostudies-literatureUnknown23(1)<h4>Background</h4>Renal cell carcinoma (RCC) is a hypermetabolic disease. Abnormal up-regulation of glycolytic signaling promotes tumor growth, and glycolytic metabolism is closely related to immunotherapy of renal cancer. The aim of the present study was to determine whether and how the glycolysis-related biomarker TCIRG1 affects aerobic glycolysis, the tumor microenvironment (TME) and malignant progression of clear cell renal cell carcinoma (ccRCC).<h4>Methods</h4>Based on The Cancer Genome Atlas (TCGA, n = 533) and the glycolysis-related gene set from MSigDB, we identified the glycolysis-related gene TCIRG1 by bioinformatics analysis, analyzed its immunological properties in ccRCC and observed how it affected the biological function and glycolytic metabolism using online databases suchCancer cell internationalGlycolysis-related biomarker TCIRG1 participates in regulation of renal cell carcinoma progression and tumor immune microenvironment by affecting aerobic glycolysis and AKT/mTOR signaling pathway.PMC10468907No. 81974391, 82072806, 82173265,82002664；2022LJ002；23QC1401400；23ZR1441300；20204Y0042；21XHDB06; No. 2020-QN-02Pan XQian CCui XZhou WWang HSun YShi XLv JGan SDong KTian YDi SChen WGong MYang QChu JWang YfalseGlycolysis-related biomarker TCIRG1 participates in regulation of renal cell carcinoma progression and tumor immune microenvironment by affecting aerobic glycolysis and AKT/mTOR signaling pathway.<h4>Background</h4>Renal cell carcinoma (RCC) is a hypermetabolic disease. Abnormal up-regulation of glycolytic signaling promotes tumor growth, and glycolytic metabolism is closely related to immunotherapy of renal cancer. The aim of the present study was to determine whether and how the glycolysis-related biomarker TCIRG1 affects aerobic glycolysis, the tumor microenvironment (TME) and malignant progression of clear cell renal cell carcinoma (ccRCC).<h4>Methods</h4>Based on The Cancer Genome Atlas (TCGA, n = 533) and the glycolysis-related gene set from MSigDB, we identified the glycolysis-related gene TCIRG1 by bioinformatics analysis, analyzed its immunological properties in ccRCC and observed how it affected the biological function and glycolytic metabolism using online databases such2023-01-01T00:00:00Z2023 Aug2026-07-14T18:36:42.967Z2025-02-19T04:23:05.197ZS-EPMC104689073764903410.1186/s12935-023-03019-0