{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(2)"],"submitter":["Li X"],"pubmed_abstract":["ABSTRACT A prominent aspect of the post-coronavirus disease-2019 (post-COVID-19) era is long-COVID. Therefore, precise patient classification and exploration of the corresponding factors affecting long-COVID are crucial for tailored treatment strategies. Frailty is a common age-related clinical syndrome characterized by deteriorated physiological functions of multiple organ systems, which increases susceptibility to stressors. Herein, we performed an inclusion and exclusion analysis (definite COVID-19 infection diagnosis, clear underlying disease information, ≥60 years old, and repeated sampling of clinical cases) of 10,613 blood samples and identified frailty cases for further investigation. RNA-Seq data were used for differential gene expression and functional and pathway analyses. The r"],"journal":["Emerging microbes & infections"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10469413"],"repository":["biostudies-literature"],"pubmed_title":["Mast cell activation may contribute to adverse health transitions in COVID-19 patients with frailty"],"pmcid":["PMC10469413"],"pubmed_authors":["Li X","Bao Z","Zhang C"],"additional_accession":[]},"is_claimable":false,"name":"Mast cell activation may contribute to adverse health transitions in COVID-19 patients with frailty","description":"ABSTRACT A prominent aspect of the post-coronavirus disease-2019 (post-COVID-19) era is long-COVID. Therefore, precise patient classification and exploration of the corresponding factors affecting long-COVID are crucial for tailored treatment strategies. Frailty is a common age-related clinical syndrome characterized by deteriorated physiological functions of multiple organ systems, which increases susceptibility to stressors. Herein, we performed an inclusion and exclusion analysis (definite COVID-19 infection diagnosis, clear underlying disease information, ≥60 years old, and repeated sampling of clinical cases) of 10,613 blood samples and identified frailty cases for further investigation. RNA-Seq data were used for differential gene expression and functional and pathway analyses. The r","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2025-04-19T20:08:24.35Z","creation":"2025-04-19T20:08:24.35Z"},"accession":"S-EPMC10469413","cross_references":{}}