biostudies-literatureZhai LNational Natural Science Foundation of China16337-16358https://www.ebi.ac.uk/biostudies/studies/S-EPMC10469729biostudies-literatureUnknown12(15)<h4>Introduction</h4>Endometrial cancer (EC) is the most common female reproductive system cancer in developed countries with growing incidence and associated mortality, which may be due to the growing prevalence of obesity. Metabolism reprogramming including glucose, amino acid, and lipid remodeling is a hallmark of tumors. Glutamine metabolism has been reported to participate in tumor proliferation and development. This study aimed to develop a glutamine metabolism-related prognostic model for EC and explore potential targets for cancer treatment.<h4>Method</h4>Transcriptomic data and survival outcome of EC were retrieved from The Cancer Genome Atlas (TCGA). Differentially expressed genes related to glutamine metabolism were recognized and utilized to build a prognostic model by univariaCancer medicineGlutamine and amino acid metabolism as a prognostic signature and therapeutic target in endometrial cancer.PMC1046972982072861821731198220356882230050Yang XZhai LWang JCheng YfalseGlutamine and amino acid metabolism as a prognostic signature and therapeutic target in endometrial cancer.<h4>Introduction</h4>Endometrial cancer (EC) is the most common female reproductive system cancer in developed countries with growing incidence and associated mortality, which may be due to the growing prevalence of obesity. Metabolism reprogramming including glucose, amino acid, and lipid remodeling is a hallmark of tumors. Glutamine metabolism has been reported to participate in tumor proliferation and development. This study aimed to develop a glutamine metabolism-related prognostic model for EC and explore potential targets for cancer treatment.<h4>Method</h4>Transcriptomic data and survival outcome of EC were retrieved from The Cancer Genome Atlas (TCGA). Differentially expressed genes related to glutamine metabolism were recognized and utilized to build a prognostic model by univaria2023-01-01T00:00:00Z2023 Aug2025-06-27T03:05:44.323Z2025-04-19T20:05:48.433ZS-EPMC104697293738755910.1002/cam4.6256