{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(3)"],"submitter":["RAF and RENO-EXTEND Investigators*"],"pubmed_abstract":["<h4>Introduction</h4>Ischaemic stroke patients with atrial fibrillation (AF) are at high risk of stroke recurrence despite oral anticoagulation therapy. Patients with cardiovascular comorbidities may take both antiplatelet and oral anticoagulation therapy (OAC/AP). Our study aims to evaluate the safety and efficacy of OAC/AP therapy as secondary prevention in people with AF and ischaemic stroke.<h4>Patients and methods</h4>We performed a post-hoc analysis of pooled individual data from multicenter prospective cohort studies and compared outcomes in the OAC/AP cohort and patients on DOAC/VKA anticoagulation alone (OAC cohort). Primary outcome was a composite of ischaemic stroke, systemic embolism, intracranial bleeding, and major extracranial bleeding, while secondary outcomes were ischaemi"],"journal":["European stroke journal"],"pagination":["722-730"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10472945"],"repository":["biostudies-literature"],"pubmed_title":["Risk of recurrent stroke in patients with atrial fibrillation treated with oral anticoagulants alone or in combination with anti-platelet therapy."],"pmcid":["PMC10472945"],"pubmed_authors":["Schomer A","Pallesen LP","Canavero I","Plocco M","Chondrogianni M","Scoditti U","Corea F","Ulivi L","Girardi L","Denti L","Pezzini A","Kargiotis O","Rota E","Polymeris AA","Risitano A","Tassi R","Agnelli G","Sacco S","Halvatsiotis P","Gentile L","Acampa M","Zuurbier S","Leone De Magistris I","Mannino M","Buehrer M","Gourbali V","Ntais E","Furie KL","Flomin Y","Pieroni A","Tsivgoulis G","Schirinzi E","Genovese A","Makaritsis K","Caliandro P","McTaggart R","Pantoni L","Palaiodimou L","Loos CMJ","Del Sette M","Stretz C","Bonetti B","Galati F","Tassinari T","Gasparro A","Carletti M","Petraglia L","Athanasakis G","Sohn SI","Tatlisumak T","Bandini F","Ferrari E","Dittrich T","Barlinn K","Barlinn J","Kala N","Paciaroni M","Sagris D","Tadi P","Padroni M","Rigatelli A","Acciarresi M","Ornello R","Karagkiozi E","Orlandi G","Jayaraman M","Marcheselli S","Chiti A","Reale G","Csiba L","Lochner P","Silvestrelli G","Reznik M","Zauli A","Letteri F","Popovic N","Salerno A","Bavaud O","Bellesini M","Vannucchi V","Putaala J","Volodina V","Giorli E","Remillard S","Calabresi P","Vadikolias K","Palmerini F","Bertora P","Giannini N","Karapanayiotides T","Engelter ST","Cronshaw R","Martini G","Marco De Marchis G","Mac Grory B","Masotti L","Venti M","Saia V","Terruso V","Mumoli N","Arnao V","Toni D","Zedde M","Deleu D","Becattini C","Pavolucci L","Dawson J","Pegoraro S","Giannopoulos S","Grifoni E","Szabo L","Cottone S","Doronin B","D'Amore C","Chiara Caselli M","Michel P","Guideri F","Maccarrone M","Zabzuni D","RAF and RENO-EXTEND Investigators*","Strbian D","Rueckert C","Lyrer P","Kosmidou M","Lorenzini G","Giuntini M","Magoni M","Liantinioti C","Baldi A","Antonenko K","Falcou A","Vanacker P","Poli L","Porta C","Abdul-Rahim A","Strambo D","Monaco S","Maria Lotti E","Mancuso M","Yaghi S","Rosa S","Alberti A","Maimone Baronello M","Yperzeele L","Ntaios G","Romoli M","Marco M","Ageno W","Ciccone A","Emanuele Saggese C","Diomedi M","Aridon P","Cancelloni V","Caso V","Bakola E","Eskandari A","Lanari A","Tiseo C","Imberti D","Cappellari M","Rocco A","Julian Seiffge D","Giulia Mosconi M","Giustozzi M","Tomppo L","Emiliani A","Zietz A"],"additional_accession":[]},"is_claimable":false,"name":"Risk of recurrent stroke in patients with atrial fibrillation treated with oral anticoagulants alone or in combination with anti-platelet therapy.","description":"<h4>Introduction</h4>Ischaemic stroke patients with atrial fibrillation (AF) are at high risk of stroke recurrence despite oral anticoagulation therapy. Patients with cardiovascular comorbidities may take both antiplatelet and oral anticoagulation therapy (OAC/AP). Our study aims to evaluate the safety and efficacy of OAC/AP therapy as secondary prevention in people with AF and ischaemic stroke.<h4>Patients and methods</h4>We performed a post-hoc analysis of pooled individual data from multicenter prospective cohort studies and compared outcomes in the OAC/AP cohort and patients on DOAC/VKA anticoagulation alone (OAC cohort). Primary outcome was a composite of ischaemic stroke, systemic embolism, intracranial bleeding, and major extracranial bleeding, while secondary outcomes were ischaemi","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Sep","modification":"2026-07-14T18:00:43.67Z","creation":"2024-11-05T20:00:33.43Z"},"accession":"S-EPMC10472945","cross_references":{"pubmed":["37458099"],"doi":["10.1177/23969873231183211"]}}