biostudies-literatureUnknown95Martinez-Sanz J<h4>Background</h4>While a low CD4/CD8 ratio during HIV treatment correlates with immunosenescence, its value in identifying patients at an increased risk for clinical events remains unclear.<h4>Methods</h4>We analyzed data from the CoRIS cohort to determine whether CD4 count, CD8 count, and CD4/CD8 ratio at year two of antiretroviral therapy (ART) could predict the risk of serious non-AIDS events (SNAEs) during the next five years. These included major adverse cardiovascular events, non-AIDS-defining malignancies, and non-accidental deaths. We used pooled logistic regression with inverse probability weighting to estimate the survival curves and cumulative risk of clinical events.<h4>Findings</h4>The study included 4625 participants, 83% male, of whom 200 (4.3%) experienced an SNAE during EBioMedicine104773https://www.ebi.ac.uk/biostudies/studies/S-EPMC10474064biostudies-literatureExpanding HIV clinical monitoring: the role of CD4, CD8, and CD4/CD8 ratio in predicting non-AIDS events.PMC10474064Giner LSantos ALVinuela LSerrano SArco ADMerino EGomez CCarrillo IGonzalez-Ruano PFerrer ADronda FOlalla JFanjul FJGutierrez Ide Miguel JPasquau FRull ASegarra ICastro JMGracia MMayoral MAntela AGutierrez SMasip JPascual JFAldamiz-Echevarria TSaez EAlcaraz AAlvarez-Rodriguez ITorre JAlcaraz BGutierrez ARoman AROrviz ETapia EGutierrez FRamirez MSaez CHernando MAGarcia BLAsensi VAyerdi OGonzalez JSantacreu MNavarro MLRiera MPoveda EGonzalez CViciana IMorano LMoreno CPeraire JMoreno ECurran AAlberto de Zarraga MGomez JLGuirao EBaza BBernal ELopez SAnguita FSanchez-Cerrillo IRubio RCampo SDSantos JRuiz Sancho AMoreno AMasia MLopez PLopez JSanchez-Paya JMuga RArnalich FLopez MIborra ACastillo ALopez ISalavert MAmador CMunoz-Fernandez MAHontanon VGonzalez-Baeza AMartinez OJLosada ECuellar SMurillas JCabello NNovella MAbellan JGBarrios AMoreno SMartinez-Sanz JDuenas CPrieto LLopez MVCabello ACamino XMoreno VPerez-Martinez LGaliana ADiaz-Alvarez JSagastagoitia IReal LMSanmarti MFalco VSanchiz MPulido FAlba VTelleria PCairo MAramburu MJHernandez JGomez MALlaves SIribarren JAAleman MRMalmierca EHernandez CIsbert SCBalsalobre LGarcia-Gazalla MGarcia MNunez MJGarcia-Bujalance SCarrio JCGarcia JDalmau DMartinez LGarcia FMartinez MGarcia GVivancos MJMellado MJChueca NGarcia DFuster DMartinez CArce OPascual RPrada JLVelli PGonzalez-Serna AOcampo AVera FJGorgolas MMetola LPadilla SVidal APerez APerez DAlonso MMNavarro GMarti ALopez-Cortes LFNavarro JPadilla BArazo PPerez IMartin-Carbonero MLMontero MMunoz AAlvarez PPerez LRodriguez JCBallesteros JPerez JRivero MHerrero CLopez JCBusca CAlvarez MGijon PRoca CReparaz JBautista AVilchez HHAlvarez BPerez VPierola Bde Miguel RNavarro RRuiz-Sancho Ade Salazar ABotella APena MSendagorta EPenaranda MCano JCardinanos JLombide IEsteban RCorona DCastro ABlanco JRBlanes MGonzalez MISaumoy MKortajarena XRuiz MPAlonso NSanchez MMerlos MASuarez-Garcia ICoRISMartin ERon RMartin LCiudad MSantos ILVallejo ASainz TJuarez ARSerrano-Villar SDelgado ATiraboschi JMFont RTomas CSanchez MJMacias JGonzalez-Garcia JFrias MVidal FValencia EGarcia-Fraile LVillalba MCMedina LMJarrin IIbarguren MRivas Carmenado MEBermejo LEspineira SAzkune HRosas MGarcia JVde Lagarde MSamperiz GCorma AAiello FFanciulli CCampins AASanz NOteo JASanz JTelenti GPalacios RPolo VSanz MBerenguer JGil LAgullo VGuillen LHerranz PTorres RTasias MSuarez-Zarracina TMontejano RGil CFuentes ABurgos JVargas MDel Romero JTorrus DFernandez MRibas MAFernandez JGarcia MCBravo JHomar FPousada GPortilla JPortilla IMiralles CIzquierdo RGarcia-Pardo GVera MXercavins MRincon PRuiz IPatino LGalindo MJAngel von Wichmann MBoix VDiaz-Flores FAdsuar ACalvet MAlgado JTRial DBertomeu FGMachuca IArribas JRPerez MJVinuesa DMauleon EPelazas RGoikoetxea MMontes MLPernas BBarber XOlona MIbarra VCamacho AIbarra SReus SPineda JARava MBernardino JIVilades CPuerta TDescalzo VEgues XJaen ARodes BSilva AKRobledano CMartinez-Lacasa JSanvisens APinto AGalera CSanchez Guirao AJDiez CRua GRodriguez LYeregui EGarcia JABustinduy MJEspinosa NRodriguez CFerrero OLIbero CCasado JLAgea ICorral SHermida JMRaposo MBisbal OPayeras APlanas BVilasaro MNOmar MImaz AVazquez PCamara MMAlbendin HGoenaga MALirola ALScevola SCArranz ANovoa CPerez-Valero IEscosa LMena APerez-Molina JACervero MTejerina FEstrada VCalabuig ESuanzes PMirena JfalseExpanding HIV clinical monitoring: the role of CD4, CD8, and CD4/CD8 ratio in predicting non-AIDS events.<h4>Background</h4>While a low CD4/CD8 ratio during HIV treatment correlates with immunosenescence, its value in identifying patients at an increased risk for clinical events remains unclear.<h4>Methods</h4>We analyzed data from the CoRIS cohort to determine whether CD4 count, CD8 count, and CD4/CD8 ratio at year two of antiretroviral therapy (ART) could predict the risk of serious non-AIDS events (SNAEs) during the next five years. These included major adverse cardiovascular events, non-AIDS-defining malignancies, and non-accidental deaths. We used pooled logistic regression with inverse probability weighting to estimate the survival curves and cumulative risk of clinical events.<h4>Findings</h4>The study included 4625 participants, 83% male, of whom 200 (4.3%) experienced an SNAE during 2023-01-01T00:00:00Z2023 Aug2025-04-04T11:26:13.426Z2025-04-04T11:26:13.426ZS-EPMC104740643763993810.1016/j.ebiom.2023.104773