{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pu J"],"funding":["Guangxi Science and Technology plan Project","Guangxi Natural Science Foundation Project"],"pagination":["3649-3665"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10475779"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["114(9)"],"pubmed_abstract":["As an epitranscriptomic modulation manner, N<sup>6</sup> -methyladenosine (m<sup>6</sup> A) modification plays important roles in various diseases, including hepatocellular carcinoma (HCC). m<sup>6</sup> A modification affects the fate of RNAs. The potential contributions of m<sup>6</sup> A to the functions of RNA still need further investigation. In this study, we identified long noncoding RNA FAM111A-DT as an m<sup>6</sup> A-modified RNA and confirmed three m<sup>6</sup> A sites on FAM111A-DT. The m<sup>6</sup> A modification level of FAM111A-DT was increased in HCC tissues and cell lines, and increased m<sup>6</sup> A level was correlated with poor survival of HCC patients. m<sup>6</sup> A modification increased the stability of FAM111A-DT transcript, whose expression level showed simil"],"journal":["Cancer science"],"pubmed_title":["N<sup>6</sup> -methyladenosine-modified FAM111A-DT promotes hepatocellular carcinoma growth via epigenetically activating FAM111A."],"pmcid":["PMC10475779"],"funding_grant_id":["2021AC20006","2019GXNSFBA245023","2020GXNSFAA259019"],"pubmed_authors":["Huang Y","Wei Q","Huang Z","Yang M","Fang Q","Pu J","Wei H","Nian J","Wang J","Xu Z","Liu G","Wu X"],"additional_accession":[]},"is_claimable":false,"name":"N<sup>6</sup> -methyladenosine-modified FAM111A-DT promotes hepatocellular carcinoma growth via epigenetically activating FAM111A.","description":"As an epitranscriptomic modulation manner, N<sup>6</sup> -methyladenosine (m<sup>6</sup> A) modification plays important roles in various diseases, including hepatocellular carcinoma (HCC). m<sup>6</sup> A modification affects the fate of RNAs. The potential contributions of m<sup>6</sup> A to the functions of RNA still need further investigation. In this study, we identified long noncoding RNA FAM111A-DT as an m<sup>6</sup> A-modified RNA and confirmed three m<sup>6</sup> A sites on FAM111A-DT. The m<sup>6</sup> A modification level of FAM111A-DT was increased in HCC tissues and cell lines, and increased m<sup>6</sup> A level was correlated with poor survival of HCC patients. m<sup>6</sup> A modification increased the stability of FAM111A-DT transcript, whose expression level showed simil","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Sep","modification":"2026-05-28T18:05:22.332Z","creation":"2025-04-07T04:14:12.772Z"},"accession":"S-EPMC10475779","cross_references":{"pubmed":["37400994"],"doi":["10.1111/cas.15886"]}}