biostudies-literaturePu JGuangxi Science and Technology plan ProjectGuangxi Natural Science Foundation Project3649-3665https://www.ebi.ac.uk/biostudies/studies/S-EPMC10475779biostudies-literatureUnknown114(9)As an epitranscriptomic modulation manner, N⁶ -methyladenosine (m⁶ A) modification plays important roles in various diseases, including hepatocellular carcinoma (HCC). m⁶ A modification affects the fate of RNAs. The potential contributions of m⁶ A to the functions of RNA still need further investigation. In this study, we identified long noncoding RNA FAM111A-DT as an m⁶ A-modified RNA and confirmed three m⁶ A sites on FAM111A-DT. The m⁶ A modification level of FAM111A-DT was increased in HCC tissues and cell lines, and increased m⁶ A level was correlated with poor survival of HCC patients. m⁶ A modification increased the stability of FAM111A-DT transcript, whose expression level showed similCancer scienceN⁶ -methyladenosine-modified FAM111A-DT promotes hepatocellular carcinoma growth via epigenetically activating FAM111A.PMC104757792021AC200062019GXNSFBA2450232020GXNSFAA259019Huang YWei QHuang ZYang MFang QPu JWei HNian JWang JXu ZLiu GWu XfalseN⁶ -methyladenosine-modified FAM111A-DT promotes hepatocellular carcinoma growth via epigenetically activating FAM111A.As an epitranscriptomic modulation manner, N⁶ -methyladenosine (m⁶ A) modification plays important roles in various diseases, including hepatocellular carcinoma (HCC). m⁶ A modification affects the fate of RNAs. The potential contributions of m⁶ A to the functions of RNA still need further investigation. In this study, we identified long noncoding RNA FAM111A-DT as an m⁶ A-modified RNA and confirmed three m⁶ A sites on FAM111A-DT. The m⁶ A modification level of FAM111A-DT was increased in HCC tissues and cell lines, and increased m⁶ A level was correlated with poor survival of HCC patients. m⁶ A modification increased the stability of FAM111A-DT transcript, whose expression level showed simil2023-01-01T00:00:00Z2023 Sep2026-05-28T18:05:22.332Z2025-04-07T04:14:12.772ZS-EPMC104757793740099410.1111/cas.15886