{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Luyapan J"],"funding":["National Library of Medicine","World Health Organization","National Institute of Health","National Cancer Institute","NCI NIH HHS","NLM NIH HHS","Cancer Prevention Research Institute of Texas"],"pagination":["2842-2855"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10481107"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["32(18)"],"pubmed_abstract":["Pulmonary surfactant is a lipoprotein synthesized and secreted by alveolar type II cells in lung. We evaluated the associations between 200,139 single nucleotide polymorphisms (SNPs) of 40 surfactant-related genes and lung cancer risk using genotyped data from two independent lung cancer genome-wide association studies. Discovery data included 18,082 cases and 13,780 controls of European ancestry. Replication data included 1,914 cases and 3,065 controls of European descent. Using multivariate logistic regression, we found novel SNPs in surfactant-related genes CTSH [rs34577742 C > T, odds ratio (OR) = 0.90, 95% confidence interval (CI) = 0.89-0.93, P = 7.64 × 10-9] and SFTA2 (rs3095153 G > A, OR = 1.16, 95% CI = 1.10-1.21, P = 1.27 × 10-9) associated with overall lung cancer in the discove"],"journal":["Human molecular genetics"],"pubmed_title":["Candidate pathway analysis of surfactant proteins identifies CTSH and SFTA2 that influences lung cancer risk."],"pmcid":["PMC10481107"],"funding_grant_id":["P30 CA177558","RR170048","5U01CA209414","001","R35 CA197449","U19CA203654","T32 LM012204","U01 CA209414","T32LM012204","U19 CA203654"],"pubmed_authors":["Zienolddiny S","McKay J","Davies MP","Christiani DC","Amos CI","Taylor F","Hung RJ","Grankvist K","Lazarus P","Luyapan J","Kiemeney LA","Brennan P","Tardon A","Xiao X","Woll PJ","Cox A","Chen C","Rosenberger A","Arnold SM","MacKenzie TA","Li Z","Landi MT","Lam S","Johansson M","Bosse Y","Field JK","Liu G","Fernandez-Tardon G"],"additional_accession":[]},"is_claimable":false,"name":"Candidate pathway analysis of surfactant proteins identifies CTSH and SFTA2 that influences lung cancer risk.","description":"Pulmonary surfactant is a lipoprotein synthesized and secreted by alveolar type II cells in lung. We evaluated the associations between 200,139 single nucleotide polymorphisms (SNPs) of 40 surfactant-related genes and lung cancer risk using genotyped data from two independent lung cancer genome-wide association studies. Discovery data included 18,082 cases and 13,780 controls of European ancestry. Replication data included 1,914 cases and 3,065 controls of European descent. Using multivariate logistic regression, we found novel SNPs in surfactant-related genes CTSH [rs34577742 C > T, odds ratio (OR) = 0.90, 95% confidence interval (CI) = 0.89-0.93, P = 7.64 × 10-9] and SFTA2 (rs3095153 G > A, OR = 1.16, 95% CI = 1.10-1.21, P = 1.27 × 10-9) associated with overall lung cancer in the discove","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Sep","modification":"2026-06-01T16:29:46.013Z","creation":"2025-04-04T14:46:58.188Z"},"accession":"S-EPMC10481107","cross_references":{"pubmed":["37471639"],"doi":["10.1093/hmg/ddad095"]}}