{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Eichler CE"],"funding":["Princeton University","China Scholarship Council","National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["e1010877"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10484445"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(8)"],"pubmed_abstract":["Localization of oskar mRNA to the posterior of the Drosophila oocyte is essential for abdominal patterning and germline development. oskar localization is a multi-step process involving temporally and mechanistically distinct transport modes. Numerous cis-acting elements and trans-acting factors have been identified that mediate earlier motor-dependent transport steps leading to an initial accumulation of oskar at the posterior. Little is known, however, about the requirements for the later localization phase, which depends on cytoplasmic flows and results in the accumulation of large oskar ribonucleoprotein granules, called founder granules, by the end of oogenesis. Using super-resolution microscopy, we show that founder granules are agglomerates of smaller oskar transport particles. In c"],"journal":["PLoS genetics"],"pubmed_title":["Localization of oskar mRNA by agglomeration in ribonucleoprotein granules."],"pmcid":["PMC10484445"],"funding_grant_id":["R35 GM126967","T32 GM007388","pre-doctoral fellowship"],"pubmed_authors":["Li H","Grunberg ME","Eichler CE","Gavis ER"],"additional_accession":[]},"is_claimable":false,"name":"Localization of oskar mRNA by agglomeration in ribonucleoprotein granules.","description":"Localization of oskar mRNA to the posterior of the Drosophila oocyte is essential for abdominal patterning and germline development. oskar localization is a multi-step process involving temporally and mechanistically distinct transport modes. Numerous cis-acting elements and trans-acting factors have been identified that mediate earlier motor-dependent transport steps leading to an initial accumulation of oskar at the posterior. Little is known, however, about the requirements for the later localization phase, which depends on cytoplasmic flows and results in the accumulation of large oskar ribonucleoprotein granules, called founder granules, by the end of oogenesis. Using super-resolution microscopy, we show that founder granules are agglomerates of smaller oskar transport particles. In c","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2025-04-05T12:36:04.067Z","creation":"2025-04-05T12:36:04.067Z"},"accession":"S-EPMC10484445","cross_references":{"pubmed":["37624861"],"doi":["10.1371/journal.pgen.1010877"]}}