{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Olivier M"],"funding":["CNRS","Université Clermont-Auvergne","China Scholar Council fellowships","Inserm","Institut Universitaire de France","Auvergne Regional Council","European Union under the Fonds Européen de Développement Régional","Ministére de l'Education Nationale, de la Formation professionnelle, de l'Enseignement Supérieur et de la Recherche Scientifique"],"pagination":["8463-8479"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10484728"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["51(16)"],"pubmed_abstract":["Transcriptional silencing is an essential mechanism for controlling the expression of genes, transgenes and heterochromatic repeats through specific epigenetic marks on chromatin that are maintained during DNA replication. In Arabidopsis, silenced transgenes and heterochromatic sequences are typically associated with high levels of DNA methylation, while silenced genes are enriched in H3K27me3. Reactivation of these loci is often correlated with decreased levels of these repressive epigenetic marks. Here, we report that the DNA helicase REGULATOR OF TELOMERE ELONGATION 1 (RTEL1) is required for transcriptional silencing. RTEL1 deficiency causes upregulation of many genes enriched in H3K27me3 accompanied by a moderate decrease in this mark, but no loss of DNA methylation at reactivated hete"],"journal":["Nucleic acids research"],"pubmed_title":["RTEL1 is required for silencing and epigenome stability."],"pmcid":["PMC10484728"],"funding_grant_id":["201806690005","AV0015348"],"pubmed_authors":["Latrasse D","Pelissier T","Huang Y","Olivier M","Benhamed M","Mathieu O","Hesketh A","Pouch-Pelissier MN"],"additional_accession":[]},"is_claimable":false,"name":"RTEL1 is required for silencing and epigenome stability.","description":"Transcriptional silencing is an essential mechanism for controlling the expression of genes, transgenes and heterochromatic repeats through specific epigenetic marks on chromatin that are maintained during DNA replication. In Arabidopsis, silenced transgenes and heterochromatic sequences are typically associated with high levels of DNA methylation, while silenced genes are enriched in H3K27me3. Reactivation of these loci is often correlated with decreased levels of these repressive epigenetic marks. Here, we report that the DNA helicase REGULATOR OF TELOMERE ELONGATION 1 (RTEL1) is required for transcriptional silencing. RTEL1 deficiency causes upregulation of many genes enriched in H3K27me3 accompanied by a moderate decrease in this mark, but no loss of DNA methylation at reactivated hete","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Sep","modification":"2025-07-09T03:04:45.762Z","creation":"2025-04-21T15:12:59.924Z"},"accession":"S-EPMC10484728","cross_references":{"pubmed":["37471026"],"doi":["10.1093/nar/gkad610"]}}