{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wenger A"],"funding":["Novo Nordisk Fonden (Novo Nordisk Foundation)","EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 Marie Skłodowska-Curie Actions (H2020 Excellent Science - Marie Skłodowska-Curie Actions)","European Research Council","Det Frie Forskningsråd (Danish Council for Independent Research)","Lundbeckfonden (Lundbeck Foundation)","Danmarks Grundforskningsfond (Danish National Research Foundation)"],"pagination":["1567-1578"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10484787"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["55(9)"],"pubmed_abstract":["Modified parental histones are segregated symmetrically to daughter DNA strands during replication and can be inherited through mitosis. How this may sustain the epigenome and cell identity remains unknown. Here we show that transmission of histone-based information during DNA replication maintains epigenome fidelity and embryonic stem cell plasticity. Asymmetric segregation of parental histones H3-H4 in MCM2-2A mutants compromised mitotic inheritance of histone modifications and globally altered the epigenome. This included widespread spurious deposition of repressive modifications, suggesting elevated epigenetic noise. Moreover, H3K9me3 loss at repeats caused derepression and H3K27me3 redistribution across bivalent promoters correlated with misexpression of developmental genes. MCM2-2A m"],"journal":["Nature genetics"],"pubmed_title":["Symmetric inheritance of parental histones governs epigenome maintenance and embryonic stem cell identity."],"pmcid":["PMC10484787"],"funding_grant_id":["NNF17CC0027852","6108-00038B","StG no. 638273","146375","7016-00042B; 4092-00404B","724436","R208-2015-2872","846375","NNF14CC0001","8020-00100B","ERC CoG no. 724436","R198-2015-269","R198-2015-412","NNF18OC0052570, NNF20OC0059796","DNRF116","638273"],"pubmed_authors":["Solis-Mezarino V","Biran A","Imhof A","Flury V","Andersson R","Groth A","Reveron-Gomez N","Volker-Albert M","Alcaraz N","Sell AC","Krautz R","Redo-Riveiro A","Wenger A","Brickman JM"],"additional_accession":[]},"is_claimable":false,"name":"Symmetric inheritance of parental histones governs epigenome maintenance and embryonic stem cell identity.","description":"Modified parental histones are segregated symmetrically to daughter DNA strands during replication and can be inherited through mitosis. How this may sustain the epigenome and cell identity remains unknown. Here we show that transmission of histone-based information during DNA replication maintains epigenome fidelity and embryonic stem cell plasticity. Asymmetric segregation of parental histones H3-H4 in MCM2-2A mutants compromised mitotic inheritance of histone modifications and globally altered the epigenome. This included widespread spurious deposition of repressive modifications, suggesting elevated epigenetic noise. Moreover, H3K9me3 loss at repeats caused derepression and H3K27me3 redistribution across bivalent promoters correlated with misexpression of developmental genes. MCM2-2A m","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Sep","modification":"2025-04-05T12:36:15.279Z","creation":"2025-04-05T12:36:15.279Z"},"accession":"S-EPMC10484787","cross_references":{"pubmed":["37666988"],"doi":["10.1038/s41588-023-01476-x"]}}