biostudies-literatureUnknown12(8)Li H<h4>Background</h4>The interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) gene is strongly associated with disease activity index of childhood systemic lupus erythematosus (SLE). However, whether <i>IFIT1</i>-regulated gene expression is the molecular basis of the pathogenesis of SLE has not been fully investigated.<h4>Methods</h4>Dataset GSE11909 was used to analyze the expression profiles of <i>IFIT1</i> gene in 103 SLE cases and 12 healthy individuals. Differentially expressed genes (DEGs)-affected by <i>IFIT1</i> gene were screened between the case group and control group, followed by gene function analysis. The clinical diagnostic potential of the least absolute shrinkage and selection operator (LASSO) model, established based on the expression profiles of <i>IFIT1</iTranslational pediatrics1517-1526https://www.ebi.ac.uk/biostudies/studies/S-EPMC10485643biostudies-literatureBioinformatic analysis of immune-related transcriptome affected by <i>IFIT1</i> gene in childhood systemic lupus erythematosus.PMC10485643Li HHuang CHuang TWang TLi BXiang WHai YfalseBioinformatic analysis of immune-related transcriptome affected by <i>IFIT1</i> gene in childhood systemic lupus erythematosus.<h4>Background</h4>The interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) gene is strongly associated with disease activity index of childhood systemic lupus erythematosus (SLE). However, whether <i>IFIT1</i>-regulated gene expression is the molecular basis of the pathogenesis of SLE has not been fully investigated.<h4>Methods</h4>Dataset GSE11909 was used to analyze the expression profiles of <i>IFIT1</i> gene in 103 SLE cases and 12 healthy individuals. Differentially expressed genes (DEGs)-affected by <i>IFIT1</i> gene were screened between the case group and control group, followed by gene function analysis. The clinical diagnostic potential of the least absolute shrinkage and selection operator (LASSO) model, established based on the expression profiles of <i>IFIT1</i2023-01-01T00:00:00Z2023 Aug2025-04-04T19:37:44.774Z2025-04-04T19:37:44.774ZS-EPMC104856433769254110.21037/tp-23-365