{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(17)"],"submitter":["Chen AL"],"funding":["an unrestricted gift from Alan J. Smith and Marita Smith"],"pubmed_abstract":["Electroreception through ampullae of Lorenzini in the little skate, <i>Leucoraja erinacea</i>, involves functional coupling between voltage-activated calcium channels (CaV1.3, <i>cacna1d</i>) and calcium-activated big-conductance potassium (BK) channels (BK, <i>kcnma1</i>). Whole-mount confocal microscopy was used to characterize the pleiotropic expression of BK and CaV1.3 in intact ampullae. BK and CaV1.3 are co-expressed in electrosensory cell plasma membranes, nuclear envelopes and kinocilia. Nuclear localization sequences (NLS) were predicted in BK and CaV1.3 by bioinformatic sequence analyses. The BK NLS is bipartite, occurs at an alternative splice site for the mammalian STREX exon and contains sequence targets for post-translational phosphorylation. Nuclear localization of skate BK "],"journal":["Cells"],"pagination":["2125"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10486799"],"repository":["biostudies-literature"],"pubmed_title":["Calcium-Activated Big-Conductance (BK) Potassium Channels Traffic through Nuclear Envelopes into Kinocilia in Ray Electrosensory Cells."],"pmcid":["PMC10486799"],"pubmed_authors":["Kao PN","Shi L","Chen AL","Wu TH","Clusin WT"],"additional_accession":[]},"is_claimable":false,"name":"Calcium-Activated Big-Conductance (BK) Potassium Channels Traffic through Nuclear Envelopes into Kinocilia in Ray Electrosensory Cells.","description":"Electroreception through ampullae of Lorenzini in the little skate, <i>Leucoraja erinacea</i>, involves functional coupling between voltage-activated calcium channels (CaV1.3, <i>cacna1d</i>) and calcium-activated big-conductance potassium (BK) channels (BK, <i>kcnma1</i>). Whole-mount confocal microscopy was used to characterize the pleiotropic expression of BK and CaV1.3 in intact ampullae. BK and CaV1.3 are co-expressed in electrosensory cell plasma membranes, nuclear envelopes and kinocilia. Nuclear localization sequences (NLS) were predicted in BK and CaV1.3 by bioinformatic sequence analyses. The BK NLS is bipartite, occurs at an alternative splice site for the mammalian STREX exon and contains sequence targets for post-translational phosphorylation. Nuclear localization of skate BK ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2026-04-07T15:41:20.978Z","creation":"2025-02-19T04:01:44.259Z"},"accession":"S-EPMC10486799","cross_references":{"pubmed":["37681857"],"doi":["10.3390/cells12172125"]}}