biostudies-literatureUnknown14Hansel M<h4>Objective</h4>Patients' olfactory function after autoimmune encephalitis (AE) involving limbic structures may be impaired. This study aimed to characterize olfactory function in patients after autoimmune encephalitides.<h4>Methods</h4>A case-control study was performed including 11 AE patients with antibodies against NMDAR (<i>n</i> = 4), GAD (<i>n</i> = 3), VGKC (<i>n</i> = 3) and antibody-negative AE (<i>n</i> = 1) and a control group of 12 patients with pneumococcal meningo-encephalitis (PC). In subgroup analyses, AE patients with and without NMDAR-antibodies were compared. Olfactory function was assessed using the Sniffin Sticks test and the resulting TDI-score (threshold, discrimination, identification). Involvement of limbic structures was evaluated on imaging data (MRI). StatistFrontiers in neurology1225975https://www.ebi.ac.uk/biostudies/studies/S-EPMC10486887biostudies-literatureOlfactory dysfunction after autoimmune encephalitis depending on the antibody type and limbic MRI pathologies.PMC10486887Schneider HReichmann HSchmitz-Peiffer HHansel MHahner AfalseOlfactory dysfunction after autoimmune encephalitis depending on the antibody type and limbic MRI pathologies.<h4>Objective</h4>Patients' olfactory function after autoimmune encephalitis (AE) involving limbic structures may be impaired. This study aimed to characterize olfactory function in patients after autoimmune encephalitides.<h4>Methods</h4>A case-control study was performed including 11 AE patients with antibodies against NMDAR (<i>n</i> = 4), GAD (<i>n</i> = 3), VGKC (<i>n</i> = 3) and antibody-negative AE (<i>n</i> = 1) and a control group of 12 patients with pneumococcal meningo-encephalitis (PC). In subgroup analyses, AE patients with and without NMDAR-antibodies were compared. Olfactory function was assessed using the Sniffin Sticks test and the resulting TDI-score (threshold, discrimination, identification). Involvement of limbic structures was evaluated on imaging data (MRI). Statist2023-01-01T00:00:00Z20232025-04-04T19:37:29.738Z2025-04-04T19:37:29.738ZS-EPMC104868873769376410.3389/fneur.2023.1225975