{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Tian C"],"pubmed_abstract":["The emergence of carbapenemase-producing <i>Acinetobacter</i> spp. has been widely reported and become a global threat. However, carbapenem-resistant <i>A. johnsonii</i> strains are relatively rare and without comprehensive genetic structure analysis, especially for isolates collected from human specimen. Here, one <i>A. johnsonii</i> AYTCM strain, co-producing NDM-1, OXA-58, and PER-1 enzymes, was isolated from sputum in China in 2018. Antimicrobial susceptibility testing showed that it was resistant to meropenem, imipenem, ceftazidime, ciprofloxacin, and cefoperazone/sulbactam. Whole-genome sequencing and bioinformatic analysis revealed that it possessed 11 plasmids. <i>bla</i> <sub>OXA-58</sub> and <i>bla</i> <sub>PER-1</sub> genes were located in the pAYTCM-1 plasmid. Especially, a com"],"journal":["Frontiers in cellular and infection microbiology"],"pagination":["1227063"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10486904"],"repository":["biostudies-literature"],"pubmed_title":["Complete genetic characterization of carbapenem-resistant <i>Acinetobacter johnsonii</i>, co-producing NDM-1, OXA-58, and PER-1 in a patient source."],"pmcid":["PMC10486904"],"pubmed_authors":["Huang D","Fan X","Ren L","Wang S","Tian C","Ying J","Fu L","Bai Y","Ma T","Song J","Zhao Y"],"additional_accession":[]},"is_claimable":false,"name":"Complete genetic characterization of carbapenem-resistant <i>Acinetobacter johnsonii</i>, co-producing NDM-1, OXA-58, and PER-1 in a patient source.","description":"The emergence of carbapenemase-producing <i>Acinetobacter</i> spp. has been widely reported and become a global threat. However, carbapenem-resistant <i>A. johnsonii</i> strains are relatively rare and without comprehensive genetic structure analysis, especially for isolates collected from human specimen. Here, one <i>A. johnsonii</i> AYTCM strain, co-producing NDM-1, OXA-58, and PER-1 enzymes, was isolated from sputum in China in 2018. Antimicrobial susceptibility testing showed that it was resistant to meropenem, imipenem, ceftazidime, ciprofloxacin, and cefoperazone/sulbactam. Whole-genome sequencing and bioinformatic analysis revealed that it possessed 11 plasmids. <i>bla</i> <sub>OXA-58</sub> and <i>bla</i> <sub>PER-1</sub> genes were located in the pAYTCM-1 plasmid. Especially, a com","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2026-04-29T02:18:38.811Z","creation":"2025-02-19T04:01:34.231Z"},"accession":"S-EPMC10486904","cross_references":{"pubmed":["37692162"],"doi":["10.3389/fcimb.2023.1227063"]}}