biostudies-literatureWei JShanxi Student's Innovation and Entrepreneurship Training ProgramScientific Research Start-up Foun-dation of Shangluo Universitythe Research and Innovation Team of Shangluo UniversityKey R&D Projects in Shaanxi Province of ChinaScientific Research Start-up Foundation of Shangluo UniversityScience and Technology Research Project of Shangluo UniversityPhD Research Start-up Fee of Shangluo UniversityShanxi Student’s Innovation and Entrepreneurship Training ProgramKey R&amp;amp;D Projects in Shaanxi Province of ChinaSpecialized Scientific Research Fund Projects of Academician Shengyong ZhangEducational Commission of Shaanxi ProvinceSpecialized Scientific Research Fund Projects6380https://www.ebi.ac.uk/biostudies/studies/S-EPMC10489798biostudies-literatureUnknown28(17)The culinary medicinal mushroom <i>Hericium erinaceus</i> holds significant global esteem and has garnered heightened interest within increasingly ageing societies due to its pronounced neuroprotective and anti-neuroinflammatory properties. Within this study, two novel diterpenes, 16-carboxy-13-<i>epi</i>-neoverrucosane (<b>1</b>) and Erinacine L (<b>2</b>); three known xylosyl cyathane diterpenoids, Erinacine A (<b>3</b>), Erinacine C (<b>4</b>), and Erinacine F (<b>5</b>); and four lanostane-type triterpenoids, and three cyclic dipeptides (<b>10</b>-<b>12</b>), in addition to orcinol (<b>13</b>), were isolated from the rice-based cultivation medium of <i>H. erinaceus</i>. Their structures were determined by NMR, HR-ESI-MS, ECD, and calculated NMR. Compound <b>1</b> marks a pioneering disMolecules (Basel, Switzerland)Unprecedented Neoverrucosane and Cyathane Diterpenoids with Anti-Neuroinflammatory Activity from Cultures of the Culinary-Medicinal Mushroom <i>Hericium erinaceus</i>.PMC1048979820JY00918YSZX00416SKY023, 22SKY1062023-YBSF-16416SKY02319SCX0522SKY106S20221139606020SKY010Qi JZhang YFeng XLHu XHui HWei JLi JYXue XfalseUnprecedented Neoverrucosane and Cyathane Diterpenoids with Anti-Neuroinflammatory Activity from Cultures of the Culinary-Medicinal Mushroom <i>Hericium erinaceus</i>.The culinary medicinal mushroom <i>Hericium erinaceus</i> holds significant global esteem and has garnered heightened interest within increasingly ageing societies due to its pronounced neuroprotective and anti-neuroinflammatory properties. Within this study, two novel diterpenes, 16-carboxy-13-<i>epi</i>-neoverrucosane (<b>1</b>) and Erinacine L (<b>2</b>); three known xylosyl cyathane diterpenoids, Erinacine A (<b>3</b>), Erinacine C (<b>4</b>), and Erinacine F (<b>5</b>); and four lanostane-type triterpenoids, and three cyclic dipeptides (<b>10</b>-<b>12</b>), in addition to orcinol (<b>13</b>), were isolated from the rice-based cultivation medium of <i>H. erinaceus</i>. Their structures were determined by NMR, HR-ESI-MS, ECD, and calculated NMR. Compound <b>1</b> marks a pioneering dis2023-01-01T00:00:00Z2023 Aug2026-04-08T15:14:17.227Z2024-10-18T10:44:25.503ZS-EPMC104897983768720910.3390/molecules28176380