{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gruber N"],"funding":["Consejo Nacional de Investigaciones Científicas y Técnicas","Universidad de Buenos Aires"],"pagination":["27391-27402"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10498151"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(39)"],"pubmed_abstract":["We present herein an in-depth study on the activity of amidinoquinoxaline <i>N</i>-oxides 1 against Gram-positive and Gram-negative anaerobic bacteria. Based on 5-phenyl-2,3-dihydropyrimidoquinoxaline <i>N</i>-oxide 1a, the selected structural variations included in our study comprise the substituents <i>α</i>- to the <i>N</i>-oxide function, the benzofused ring, substitution and quaternization of the amidine moiety, and the amidine ring size. Compounds 1 showed good to excellent antianaerobic activity, evaluated as the corresponding CIM<sub>50</sub> and CIM<sub>90</sub> values, and an antimicrobial spectrum similar to metronidazole. Six out of 13 compounds 1 had CIM<sub>90</sub> values significantly lower than the reference drug. Among them, imidazoline derivatives 1i-l were the most acti"],"journal":["RSC advances"],"pubmed_title":["Amidinoquinoxaline <i>N</i>-oxides: synthesis and activity against anaerobic bacteria."],"pmcid":["PMC10498151"],"funding_grant_id":["11220200101694CO","20020170100189BA"],"pubmed_authors":["Gonzalez Maglio DH","Paz ML","Fernandez-Canigia L","Garcia MB","Gruber N","Orelli LR","Stipa P","Bisceglia JA","Kilimciler NB"],"additional_accession":[]},"is_claimable":false,"name":"Amidinoquinoxaline <i>N</i>-oxides: synthesis and activity against anaerobic bacteria.","description":"We present herein an in-depth study on the activity of amidinoquinoxaline <i>N</i>-oxides 1 against Gram-positive and Gram-negative anaerobic bacteria. Based on 5-phenyl-2,3-dihydropyrimidoquinoxaline <i>N</i>-oxide 1a, the selected structural variations included in our study comprise the substituents <i>α</i>- to the <i>N</i>-oxide function, the benzofused ring, substitution and quaternization of the amidine moiety, and the amidine ring size. Compounds 1 showed good to excellent antianaerobic activity, evaluated as the corresponding CIM<sub>50</sub> and CIM<sub>90</sub> values, and an antimicrobial spectrum similar to metronidazole. Six out of 13 compounds 1 had CIM<sub>90</sub> values significantly lower than the reference drug. Among them, imidazoline derivatives 1i-l were the most acti","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Sep","modification":"2026-06-04T09:35:16.067Z","creation":"2024-11-13T01:22:09.172Z"},"accession":"S-EPMC10498151","cross_references":{"pubmed":["37711381"],"doi":["10.1039/d3ra01184d"]}}