{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chatterjee A"],"funding":["Department of Biotechnology, Government of West Bengal"],"pagination":["16774-16787"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10501293"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(16)"],"pubmed_abstract":["<h4>Background</h4>For various cancers, differences in response to treatment and subsequent survival period have been reported to be associated with variation in immune contextures.<h4>Aim</h4>We sought to identify whether such association exists in respect of gingivobuccal oral cancer.<h4>Materials and methods</h4>We performed deep immune profiling of tumor and margin tissues collected from 46 treatment naïve, Human Papillomavirus (HPV) negative, patients. Each patient was followed for 24 months and prognosis (recurrence/death) noted. Key findings were validated by comparing with TCGA-HNSC cohort data.<h4>Results</h4>About 28% of patients showed poor post-treatment prognosis. These patients exhibited a high probability of recurrence even within 1 year and death within 2 years. There was r"],"journal":["Cancer medicine"],"pubmed_title":["Overexpression of CD73 is associated with recurrence and poor prognosis of gingivobuccal oral cancer as revealed by transcriptome and deep immune profiling of paired tumor and margin tissues."],"pmcid":["PMC10501293"],"funding_grant_id":["BT/Med‐II/NIBMG/SyMeC/2014/Vol.II"],"pubmed_authors":["Ghosh A","Majumder PP","Arun P","Maitra A","Chaudhary A","Biswas N","Chatterjee A","Arun I","Mukherjee G"],"additional_accession":[]},"is_claimable":false,"name":"Overexpression of CD73 is associated with recurrence and poor prognosis of gingivobuccal oral cancer as revealed by transcriptome and deep immune profiling of paired tumor and margin tissues.","description":"<h4>Background</h4>For various cancers, differences in response to treatment and subsequent survival period have been reported to be associated with variation in immune contextures.<h4>Aim</h4>We sought to identify whether such association exists in respect of gingivobuccal oral cancer.<h4>Materials and methods</h4>We performed deep immune profiling of tumor and margin tissues collected from 46 treatment naïve, Human Papillomavirus (HPV) negative, patients. Each patient was followed for 24 months and prognosis (recurrence/death) noted. Key findings were validated by comparing with TCGA-HNSC cohort data.<h4>Results</h4>About 28% of patients showed poor post-treatment prognosis. These patients exhibited a high probability of recurrence even within 1 year and death within 2 years. There was r","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2025-04-22T18:23:41.312Z","creation":"2024-11-12T15:46:43.96Z"},"accession":"S-EPMC10501293","cross_references":{"pubmed":["37392167"],"doi":["10.1002/cam4.6299"]}}