biostudies-literatureChatterjee ADepartment of Biotechnology, Government of West Bengal16774-16787https://www.ebi.ac.uk/biostudies/studies/S-EPMC10501293biostudies-literatureUnknown12(16)<h4>Background</h4>For various cancers, differences in response to treatment and subsequent survival period have been reported to be associated with variation in immune contextures.<h4>Aim</h4>We sought to identify whether such association exists in respect of gingivobuccal oral cancer.<h4>Materials and methods</h4>We performed deep immune profiling of tumor and margin tissues collected from 46 treatment naïve, Human Papillomavirus (HPV) negative, patients. Each patient was followed for 24 months and prognosis (recurrence/death) noted. Key findings were validated by comparing with TCGA-HNSC cohort data.<h4>Results</h4>About 28% of patients showed poor post-treatment prognosis. These patients exhibited a high probability of recurrence even within 1 year and death within 2 years. There was rCancer medicineOverexpression of CD73 is associated with recurrence and poor prognosis of gingivobuccal oral cancer as revealed by transcriptome and deep immune profiling of paired tumor and margin tissues.PMC10501293BT/Med‐II/NIBMG/SyMeC/2014/Vol.IIGhosh AMajumder PPArun PMaitra AChaudhary ABiswas NChatterjee AArun IMukherjee GfalseOverexpression of CD73 is associated with recurrence and poor prognosis of gingivobuccal oral cancer as revealed by transcriptome and deep immune profiling of paired tumor and margin tissues.<h4>Background</h4>For various cancers, differences in response to treatment and subsequent survival period have been reported to be associated with variation in immune contextures.<h4>Aim</h4>We sought to identify whether such association exists in respect of gingivobuccal oral cancer.<h4>Materials and methods</h4>We performed deep immune profiling of tumor and margin tissues collected from 46 treatment naïve, Human Papillomavirus (HPV) negative, patients. Each patient was followed for 24 months and prognosis (recurrence/death) noted. Key findings were validated by comparing with TCGA-HNSC cohort data.<h4>Results</h4>About 28% of patients showed poor post-treatment prognosis. These patients exhibited a high probability of recurrence even within 1 year and death within 2 years. There was r2023-01-01T00:00:00Z2023 Aug2025-04-22T18:23:41.312Z2024-11-12T15:46:43.96ZS-EPMC105012933739216710.1002/cam4.6299