{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yu Y"],"funding":["Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates","Shenzhen Key Laboratory of Functional Aggregate Materials","National Natural Science Foundation of China","Natural Science Foundation of Guangdong Province","Sichuan Science and Technology Program"],"pagination":["e2302395"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10502865"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(26)"],"pubmed_abstract":["X-ray induced photodynamic therapy (X-PDT) circumvents the poor penetration depth of conventional PDT with minimal radio-resistance generation. However, conventional X-PDT typically requires inorganic scintillators as energy transducers to excite neighboring photosensitizers (PSs) to generate reactive oxygen species (ROS). Herein, a pure organic aggregation-induced emission (AIE) nanoscintillator (TBDCR NPs) that can massively generate both type I and type II ROS under direct X-ray irradiation is reported for hypoxia-tolerant X-PDT. Heteroatoms are introduced to enhance X-ray harvesting and ROS generation ability, and AIE-active TBDCR exhibits aggregation-enhanced ROS especially less oxygen-dependent hydroxyl radical (HO<sup>•-</sup> , type I) generation ability. TBDCR NPs with a distincti"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Pure Organic AIE Nanoscintillator for X-ray Mediated Type I and Type II Photodynamic Therapy."],"pmcid":["PMC10502865"],"funding_grant_id":["ZDSYS20211021111400001","82003242","22205067","2019B030301003","2023YFS0318","2021A1515011901"],"pubmed_authors":["Ni Z","Liu Y","Xie G","Zhu ZH","Zhang X","Feng G","Zhang L","Tang BZ","Xiang L","Yu Y","Lan J","Liu W"],"additional_accession":[]},"is_claimable":false,"name":"Pure Organic AIE Nanoscintillator for X-ray Mediated Type I and Type II Photodynamic Therapy.","description":"X-ray induced photodynamic therapy (X-PDT) circumvents the poor penetration depth of conventional PDT with minimal radio-resistance generation. However, conventional X-PDT typically requires inorganic scintillators as energy transducers to excite neighboring photosensitizers (PSs) to generate reactive oxygen species (ROS). Herein, a pure organic aggregation-induced emission (AIE) nanoscintillator (TBDCR NPs) that can massively generate both type I and type II ROS under direct X-ray irradiation is reported for hypoxia-tolerant X-PDT. Heteroatoms are introduced to enhance X-ray harvesting and ROS generation ability, and AIE-active TBDCR exhibits aggregation-enhanced ROS especially less oxygen-dependent hydroxyl radical (HO<sup>•-</sup> , type I) generation ability. TBDCR NPs with a distincti","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Sep","modification":"2025-04-27T03:38:50.507Z","creation":"2025-04-06T18:57:15.491Z"},"accession":"S-EPMC10502865","cross_references":{"pubmed":["37424049"],"doi":["10.1002/advs.202302395"]}}