biostudies-literatureUnknown3(5)Shen JThe use of poly(ε-caprolactone) (PCL) for biomedical applications is well established, particularly for permanent implants, due to its slow degradation rate, suitable mechanical properties, and biocompatibility. However, the slow degradation rate of PCL limits its application for short-term and temporary biomedical applications where bioabsorbability is required. To enhance the properties of PCL and to expand its biomedical applications, we developed an approach to produce PCL membranes with tunable degradation rates, mechanical properties, and biofunctional features. Specifically, we utilized electrospinning to create fibrous PCL membranes, which were then chemically modified using potassium permanganate to alter their degradability while having minimal impact on their fibrous morphology.ACS materials Au540-547https://www.ebi.ac.uk/biostudies/studies/S-EPMC10510513biostudies-literatureModified Poly(ε-caprolactone) with Tunable Degradability and Improved Biofunctionality for Regenerative Medicine.PMC10510513Shen JMoshaverinia AWeiss PSBadv MYuan WfalseModified Poly(ε-caprolactone) with Tunable Degradability and Improved Biofunctionality for Regenerative Medicine.The use of poly(ε-caprolactone) (PCL) for biomedical applications is well established, particularly for permanent implants, due to its slow degradation rate, suitable mechanical properties, and biocompatibility. However, the slow degradation rate of PCL limits its application for short-term and temporary biomedical applications where bioabsorbability is required. To enhance the properties of PCL and to expand its biomedical applications, we developed an approach to produce PCL membranes with tunable degradation rates, mechanical properties, and biofunctional features. Specifically, we utilized electrospinning to create fibrous PCL membranes, which were then chemically modified using potassium permanganate to alter their degradability while having minimal impact on their fibrous morphology.2023-01-01T00:00:00Z2023 Sep2025-04-19T04:10:37.869Z2025-04-19T04:10:37.869ZS-EPMC105105133808908910.1021/acsmaterialsau.3c00027