{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2"],"submitter":["Yan Y"],"pubmed_abstract":["Gα signaling pathway as well as the global regulator LaeA were demonstrated to positively regulate the biosynthesis of chaetoglobosin A (ChA), a promising biotic pesticide produced by <i>Chaetomium globosum</i>. Recently, the regulatory function of Zn<sub>2</sub>Cys<sub>6</sub> binuclear finger transcription factor <i>CgcheR</i> that lies within the ChA biosynthesis gene cluster has been confirmed. However, <i>CgcheR</i> was not merely a pathway specific regulator. In this study, we showed that the homologs gene of <i>CgcheR</i> (designated as <i>Cgtf1</i>) regulate ChA biosynthesis and sporulation in <i>C. globosum</i> NK102. More importantly, RNA-seq profiling demonstrated that 1,388 genes were significant differentially expressed as <i>Cgtf1</i> deleted. Among them, a putative C<sub>2</"],"journal":["Frontiers in fungal biology"],"pagination":["756104"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10512409"],"repository":["biostudies-literature"],"pubmed_title":["A Putative C<sub>2</sub>H<sub>2</sub> Transcription Factor CgTF6, Controlled by CgTF1, Negatively Regulates Chaetoglobosin A Biosynthesis in <i>Chaetomium globosum</i>."],"pmcid":["PMC10512409"],"pubmed_authors":["Xiang B","Lin Y","Hao X","Zhu X","Yan Y","Xie Q","Shen G"],"additional_accession":[]},"is_claimable":false,"name":"A Putative C<sub>2</sub>H<sub>2</sub> Transcription Factor CgTF6, Controlled by CgTF1, Negatively Regulates Chaetoglobosin A Biosynthesis in <i>Chaetomium globosum</i>.","description":"Gα signaling pathway as well as the global regulator LaeA were demonstrated to positively regulate the biosynthesis of chaetoglobosin A (ChA), a promising biotic pesticide produced by <i>Chaetomium globosum</i>. Recently, the regulatory function of Zn<sub>2</sub>Cys<sub>6</sub> binuclear finger transcription factor <i>CgcheR</i> that lies within the ChA biosynthesis gene cluster has been confirmed. However, <i>CgcheR</i> was not merely a pathway specific regulator. In this study, we showed that the homologs gene of <i>CgcheR</i> (designated as <i>Cgtf1</i>) regulate ChA biosynthesis and sporulation in <i>C. globosum</i> NK102. More importantly, RNA-seq profiling demonstrated that 1,388 genes were significant differentially expressed as <i>Cgtf1</i> deleted. Among them, a putative C<sub>2</","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-07-14T23:02:04.719Z","creation":"2024-11-19T15:14:06.638Z"},"accession":"S-EPMC10512409","cross_references":{"pubmed":["37744158"],"doi":["10.3389/ffunb.2021.756104"]}}