biostudies-literatureUnknown2Yan YGα signaling pathway as well as the global regulator LaeA were demonstrated to positively regulate the biosynthesis of chaetoglobosin A (ChA), a promising biotic pesticide produced by <i>Chaetomium globosum</i>. Recently, the regulatory function of Zn₂Cys₆ binuclear finger transcription factor <i>CgcheR</i> that lies within the ChA biosynthesis gene cluster has been confirmed. However, <i>CgcheR</i> was not merely a pathway specific regulator. In this study, we showed that the homologs gene of <i>CgcheR</i> (designated as <i>Cgtf1</i>) regulate ChA biosynthesis and sporulation in <i>C. globosum</i> NK102. More importantly, RNA-seq profiling demonstrated that 1,388 genes were significant differentially expressed as <i>Cgtf1</i> deleted. Among them, a putative C<sub>2</Frontiers in fungal biology756104https://www.ebi.ac.uk/biostudies/studies/S-EPMC10512409biostudies-literatureA Putative C₂H₂ Transcription Factor CgTF6, Controlled by CgTF1, Negatively Regulates Chaetoglobosin A Biosynthesis in <i>Chaetomium globosum</i>.PMC10512409Xiang BLin YHao XZhu XYan YXie QShen GfalseA Putative C₂H₂ Transcription Factor CgTF6, Controlled by CgTF1, Negatively Regulates Chaetoglobosin A Biosynthesis in <i>Chaetomium globosum</i>.Gα signaling pathway as well as the global regulator LaeA were demonstrated to positively regulate the biosynthesis of chaetoglobosin A (ChA), a promising biotic pesticide produced by <i>Chaetomium globosum</i>. Recently, the regulatory function of Zn₂Cys₆ binuclear finger transcription factor <i>CgcheR</i> that lies within the ChA biosynthesis gene cluster has been confirmed. However, <i>CgcheR</i> was not merely a pathway specific regulator. In this study, we showed that the homologs gene of <i>CgcheR</i> (designated as <i>Cgtf1</i>) regulate ChA biosynthesis and sporulation in <i>C. globosum</i> NK102. More importantly, RNA-seq profiling demonstrated that 1,388 genes were significant differentially expressed as <i>Cgtf1</i> deleted. Among them, a putative C<sub>2</2021-01-01T00:00:00Z20212026-07-14T23:02:04.719Z2024-11-19T15:14:06.638ZS-EPMC105124093774415810.3389/ffunb.2021.756104