biostudies-literatureUnknown10Canuti MSpecific immune suppression types have been associated with a greater risk of severe COVID-19 disease and death. We analyzed data from patients >17 years that were hospitalized for COVID-19 at the "Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico" in Milan (Lombardy, Northern Italy). The study included 1727 SARS-CoV-2-positive patients (1,131 males, median age of 65 years) hospitalized between February 2020 and November 2022. Of these, 321 (18.6%, CI: 16.8-20.4%) had at least one condition defining immune suppression. Immune suppressed subjects were more likely to have other co-morbidities (80.4% vs. 69.8%, <i>p</i> < 0.001) and be vaccinated (37% vs. 12.7%, <i>p</i> < 0.001). We evaluated the contribution of immune suppression to hospitalization during the various stages of the eFrontiers in medicine1260950https://www.ebi.ac.uk/biostudies/studies/S-EPMC10513414biostudies-literatureThe role of immune suppression in COVID-19 hospitalization: clinical and epidemiological trends over three years of SARS-CoV-2 epidemic.PMC10513414Bobbio CMaura SGianluca ZBandera AMargherita ONatalia SSimona BValter MAngelica CGrazia Eliana CMariele PCanuti MDavide MElisa FPaola SNicola MMuheberimana TCostantino GAlice RDiletta MAlice FCOVID-19 Network Study GroupAlice DCanetta CLetizia MBaldi SLChiara BBarbara FMichele De CCinzia Maria HCostanza MVilla SGiulia RLuigia SGiulia VFrancesca FGiuseppe LBarbara VStefano SGiuseppe ACarlo APMonti MCDaniele PMarta Di PMirta CAgata BLuca VSofia MCarlotta CTeresa IGiulia CBlasi FClara MEleonora TFilippo BMartina CIrene MIrena RLaura BLaura ASilvano BLudovico FLaura CMuscatello ALaura RLeonardo TTiziano LMonica SEmanuele PAgnese CGiuliana FMaria PMaria MNathalie IValentina FGiacomo GErica PPeyvandi FRaffaella RSilvia AAndrea PSilvia GMaria Teresa CSilvia DAndrea LAlessia Antonella GRiccardo UArianna LGori ARosaria BMarta MMarco VRaviglione MCRoberta GAliberti SMarco PNobili ASilvia Della FGiorgio CGiorgio BSerena LChristian FValeria CRosa LRoberta MAndrea GMarco FMarco MValeria FAnna Ludovica FNadia BValerie MValeria PValeria RArturo CMatteo CMatteo BAlessandro GAnnalisa CTettamanti MAngelo RIgor MfalseThe role of immune suppression in COVID-19 hospitalization: clinical and epidemiological trends over three years of SARS-CoV-2 epidemic.Specific immune suppression types have been associated with a greater risk of severe COVID-19 disease and death. We analyzed data from patients >17 years that were hospitalized for COVID-19 at the "Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico" in Milan (Lombardy, Northern Italy). The study included 1727 SARS-CoV-2-positive patients (1,131 males, median age of 65 years) hospitalized between February 2020 and November 2022. Of these, 321 (18.6%, CI: 16.8-20.4%) had at least one condition defining immune suppression. Immune suppressed subjects were more likely to have other co-morbidities (80.4% vs. 69.8%, <i>p</i> < 0.001) and be vaccinated (37% vs. 12.7%, <i>p</i> < 0.001). We evaluated the contribution of immune suppression to hospitalization during the various stages of the e2023-01-01T00:00:00Z20232025-05-29T16:36:24.784Z2025-05-29T16:36:24.784ZS-EPMC105134143774608310.3389/fmed.2023.1260950