{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lieder HR"],"funding":["Deutsche Forschungsgemeinschaft","Universitätsklinikum Essen","European COST Action in Cardioprotection"],"pagination":["865-876"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10517043"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["37(5)"],"pubmed_abstract":["Purpose
The role of platelets during myocardial ischemia/reperfusion (I/R) is ambivalent. They contribute to injury but also to cardioprotection. Repeated blood flow restriction and reperfusion in a tissue/organ remote from the heart (remote ischemic conditioning, RIC) reduce myocardial I/R injury and attenuate platelet activation. Whether or not platelets mediate RIC's cardioprotective signal is currently unclear.Methods and results
Venous blood from healthy volunteers (without or with pretreatment of 500/1000 mg aspirin or 180 mg ticagrelor orally, 2-3 h before the study, n = 18 each) was collected before and after RIC (3 × 5 min blood pressure cuff inflation at 200 mmHg on the left upper arm/5 min deflation). Washed platelets were isolated. Platelet-poor plasma was used "],"journal":["Cardiovascular drugs and therapy"],"pubmed_title":["Platelet-Mediated Transfer of Cardioprotection by Remote Ischemic Conditioning and Its Abrogation by Aspirin But Not by Ticagrelor."],"pmcid":["PMC10517043"],"funding_grant_id":["CA16225","SFB 1116 B8"],"pubmed_authors":["Kleinbongard P","Heusch G","Schror K","Lieder HR","Tsoumani M","Andreadou I"],"additional_accession":[]},"is_claimable":false,"name":"Platelet-Mediated Transfer of Cardioprotection by Remote Ischemic Conditioning and Its Abrogation by Aspirin But Not by Ticagrelor.","description":"Purpose
The role of platelets during myocardial ischemia/reperfusion (I/R) is ambivalent. They contribute to injury but also to cardioprotection. Repeated blood flow restriction and reperfusion in a tissue/organ remote from the heart (remote ischemic conditioning, RIC) reduce myocardial I/R injury and attenuate platelet activation. Whether or not platelets mediate RIC's cardioprotective signal is currently unclear.Methods and results
Venous blood from healthy volunteers (without or with pretreatment of 500/1000 mg aspirin or 180 mg ticagrelor orally, 2-3 h before the study, n = 18 each) was collected before and after RIC (3 × 5 min blood pressure cuff inflation at 200 mmHg on the left upper arm/5 min deflation). Washed platelets were isolated. Platelet-poor plasma was used ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Oct","modification":"2025-04-26T23:28:57.171Z","creation":"2025-04-06T17:31:42.893Z"},"accession":"S-EPMC10517043","cross_references":{"pubmed":["35595877"],"doi":["10.1007/s10557-022-07345-9"]}}