biostudies-literatureLieder HRDeutsche ForschungsgemeinschaftUniversitätsklinikum EssenEuropean COST Action in Cardioprotection865-876https://www.ebi.ac.uk/biostudies/studies/S-EPMC10517043biostudies-literatureUnknown37(5)<h4>Purpose</h4>The role of platelets during myocardial ischemia/reperfusion (I/R) is ambivalent. They contribute to injury but also to cardioprotection. Repeated blood flow restriction and reperfusion in a tissue/organ remote from the heart (remote ischemic conditioning, RIC) reduce myocardial I/R injury and attenuate platelet activation. Whether or not platelets mediate RIC's cardioprotective signal is currently unclear.<h4>Methods and results</h4>Venous blood from healthy volunteers (without or with pretreatment of 500/1000 mg aspirin or 180 mg ticagrelor orally, 2-3 h before the study, n = 18 each) was collected before and after RIC (3 × 5 min blood pressure cuff inflation at 200 mmHg on the left upper arm/5 min deflation). Washed platelets were isolated. Platelet-poor plasma was used Cardiovascular drugs and therapyPlatelet-Mediated Transfer of Cardioprotection by Remote Ischemic Conditioning and Its Abrogation by Aspirin But Not by Ticagrelor.PMC10517043CA16225SFB 1116 B8Kleinbongard PHeusch GSchror KLieder HRTsoumani MAndreadou IfalsePlatelet-Mediated Transfer of Cardioprotection by Remote Ischemic Conditioning and Its Abrogation by Aspirin But Not by Ticagrelor.<h4>Purpose</h4>The role of platelets during myocardial ischemia/reperfusion (I/R) is ambivalent. They contribute to injury but also to cardioprotection. Repeated blood flow restriction and reperfusion in a tissue/organ remote from the heart (remote ischemic conditioning, RIC) reduce myocardial I/R injury and attenuate platelet activation. Whether or not platelets mediate RIC's cardioprotective signal is currently unclear.<h4>Methods and results</h4>Venous blood from healthy volunteers (without or with pretreatment of 500/1000 mg aspirin or 180 mg ticagrelor orally, 2-3 h before the study, n = 18 each) was collected before and after RIC (3 × 5 min blood pressure cuff inflation at 200 mmHg on the left upper arm/5 min deflation). Washed platelets were isolated. Platelet-poor plasma was used 2023-01-01T00:00:00Z2023 Oct2025-04-26T23:28:57.171Z2025-04-06T17:31:42.893ZS-EPMC105170433559587710.1007/s10557-022-07345-9