{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["McCord B"],"funding":["NIHR","Horizon 2020 Framework Programme","Medical Research Council","London Advanced Therapies","Horizon 2020","National Institute for Health Research (NIHR)","Research England","University College London Hospitals Biomedical Research Centre"],"pagination":["15935"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10517962"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["Sporadic inclusion body myositis (sIBM) is an idiopathic inflammatory myopathy with invasion of CD8 T cells in muscle and aggregation of proteins in the sarcoplasm. TDP-43 and p62 are two proteins that aggregate in affected muscle, and have been suggested as specific markers for sIBM over other inflammatory myopathies. TDP-43 is also mislocalised from the nucleus to the sarcoplasm in sIBM. It is not clear if inflammation precedes protein aggregation in sIBM. This study investigated if exposure to cytotoxic inflammatory cells caused TDP-43 and p62 aggregation or TDP-43 mislocalisation in cultured myotubes. TALL-104 coculture was highly cytotoxic to myotubes after 24 h. Secretion of IFNγ and TNFα were higher in cocultures compared to monocultured TALL-104 cells, indicating activation. TALL-1"],"journal":["Scientific reports"],"pubmed_title":["Cytotoxic immune cells do not affect TDP-43 and p62 sarcoplasmic aggregation but influence TDP-43 localisation."],"pmcid":["PMC10517962"],"funding_grant_id":["874807","MR/N013867/1","London Advanced Therapies, Connecting Capabilities Fund Initiative","University College London Hospitals Biomedical Research Centre","Confidence in Collaboration Award"],"pubmed_authors":["Day RM","McCord B"],"additional_accession":[]},"is_claimable":false,"name":"Cytotoxic immune cells do not affect TDP-43 and p62 sarcoplasmic aggregation but influence TDP-43 localisation.","description":"Sporadic inclusion body myositis (sIBM) is an idiopathic inflammatory myopathy with invasion of CD8 T cells in muscle and aggregation of proteins in the sarcoplasm. TDP-43 and p62 are two proteins that aggregate in affected muscle, and have been suggested as specific markers for sIBM over other inflammatory myopathies. TDP-43 is also mislocalised from the nucleus to the sarcoplasm in sIBM. It is not clear if inflammation precedes protein aggregation in sIBM. This study investigated if exposure to cytotoxic inflammatory cells caused TDP-43 and p62 aggregation or TDP-43 mislocalisation in cultured myotubes. TALL-104 coculture was highly cytotoxic to myotubes after 24 h. Secretion of IFNγ and TNFα were higher in cocultures compared to monocultured TALL-104 cells, indicating activation. TALL-1","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Sep","modification":"2025-04-18T19:25:15.088Z","creation":"2025-04-07T07:11:03.018Z"},"accession":"S-EPMC10517962","cross_references":{"pubmed":["37741931"],"doi":["10.1038/s41598-023-42824-5"]}}