{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["164(2)"],"submitter":["Dimov D"],"funding":["Universität Bielefeld"],"pubmed_abstract":["<h4>Purpose</h4>Multifocal/multicentric glioblastomas (mGBM) account for up to 20% of all newly diagnosed glioblastomas. The present study investigates the impact of cytoreductive surgery on survival and functional outcomes in patients with mGBM.<h4>Methods</h4>We retrospectively reviewed clinical and imaging data of 71 patients with newly diagnosed primary (IDH1 wildtype) mGBM who underwent operative treatment in 2015-2020 at the authors' institution. Multicentric/multifocal growth was defined by the presence of ≥ 2 contrast enhancing lesions ≥ 1 cm apart from each other.<h4>Results</h4>36 (50.7%) patients had a resection and 35 (49.3%) a biopsy procedure. MGMT status, age, preoperative KPI and NANO scores as well as the postoperative KPI and NANO scores did not differ significantly betwe"],"journal":["Journal of neuro-oncology"],"pagination":["447-459"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10522503"],"repository":["biostudies-literature"],"pubmed_title":["The role of cytoreductive surgery in multifocal/multicentric glioblastomas."],"pmcid":["PMC10522503"],"pubmed_authors":["Berger B","Brainman D","Grote A","Coras R","Simon M","Dimov D"],"additional_accession":[]},"is_claimable":false,"name":"The role of cytoreductive surgery in multifocal/multicentric glioblastomas.","description":"<h4>Purpose</h4>Multifocal/multicentric glioblastomas (mGBM) account for up to 20% of all newly diagnosed glioblastomas. The present study investigates the impact of cytoreductive surgery on survival and functional outcomes in patients with mGBM.<h4>Methods</h4>We retrospectively reviewed clinical and imaging data of 71 patients with newly diagnosed primary (IDH1 wildtype) mGBM who underwent operative treatment in 2015-2020 at the authors' institution. Multicentric/multifocal growth was defined by the presence of ≥ 2 contrast enhancing lesions ≥ 1 cm apart from each other.<h4>Results</h4>36 (50.7%) patients had a resection and 35 (49.3%) a biopsy procedure. MGMT status, age, preoperative KPI and NANO scores as well as the postoperative KPI and NANO scores did not differ significantly betwe","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Sep","modification":"2025-04-04T21:46:06.885Z","creation":"2025-04-04T21:46:06.885Z"},"accession":"S-EPMC10522503","cross_references":{"pubmed":["37697210"],"doi":["10.1007/s11060-023-04410-7"]}}