biostudies-literatureUnknown164(2)Dimov DUniversität Bielefeld<h4>Purpose</h4>Multifocal/multicentric glioblastomas (mGBM) account for up to 20% of all newly diagnosed glioblastomas. The present study investigates the impact of cytoreductive surgery on survival and functional outcomes in patients with mGBM.<h4>Methods</h4>We retrospectively reviewed clinical and imaging data of 71 patients with newly diagnosed primary (IDH1 wildtype) mGBM who underwent operative treatment in 2015-2020 at the authors' institution. Multicentric/multifocal growth was defined by the presence of ≥ 2 contrast enhancing lesions ≥ 1 cm apart from each other.<h4>Results</h4>36 (50.7%) patients had a resection and 35 (49.3%) a biopsy procedure. MGMT status, age, preoperative KPI and NANO scores as well as the postoperative KPI and NANO scores did not differ significantly betweJournal of neuro-oncology447-459https://www.ebi.ac.uk/biostudies/studies/S-EPMC10522503biostudies-literatureThe role of cytoreductive surgery in multifocal/multicentric glioblastomas.PMC10522503Berger BBrainman DGrote ACoras RSimon MDimov DfalseThe role of cytoreductive surgery in multifocal/multicentric glioblastomas.<h4>Purpose</h4>Multifocal/multicentric glioblastomas (mGBM) account for up to 20% of all newly diagnosed glioblastomas. The present study investigates the impact of cytoreductive surgery on survival and functional outcomes in patients with mGBM.<h4>Methods</h4>We retrospectively reviewed clinical and imaging data of 71 patients with newly diagnosed primary (IDH1 wildtype) mGBM who underwent operative treatment in 2015-2020 at the authors' institution. Multicentric/multifocal growth was defined by the presence of ≥ 2 contrast enhancing lesions ≥ 1 cm apart from each other.<h4>Results</h4>36 (50.7%) patients had a resection and 35 (49.3%) a biopsy procedure. MGMT status, age, preoperative KPI and NANO scores as well as the postoperative KPI and NANO scores did not differ significantly betwe2023-01-01T00:00:00Z2023 Sep2025-04-04T21:46:06.885Z2025-04-04T21:46:06.885ZS-EPMC105225033769721010.1007/s11060-023-04410-7