biostudies-literatureForno GTau ConsortiumGlobal Brain Health InstituteNIA NIH HHSANIDTakeda Science FoundationCONICETRainwater FoundationChilean Ministry of EducationNational Institutes of HealthAlzheimer&apos;s AssociationAlzheimer's Association753-768https://www.ebi.ac.uk/biostudies/studies/S-EPMC10522796biostudies-literatureUnknown37(7)<h4>Objective</h4>Cognitive assessment able to detect impairments in the early neuropathological stages of Alzheimer's disease (AD) is urgently needed. The visual short-term memory binding task (VSTMBT) and the Free and Cued Selective Reminding Test (FCSRT) have been recommended by the neurodegenerative disease working group as promising tests to aid in the early detection of AD. In this study, we investigated their complementary value across the clinical stages of the AD continuum.<h4>Method</h4>One hundred and seventeen older adults with subjective cognitive complaint (SCC), 79 with mild cognitive impairment (MCI), 31 patients with AD dementia (ADD), and 37 cognitively unimpaired (CU) subjects, underwent assessment with the VSTMBT and the picture version of the Spanish FCSRT.<h4>Results<NeuropsychologyThe "when" matters: Evidence from memory markers in the clinical continuum of Alzheimer's disease.PMC105227961210195; 1210176; 12209952017-1818; 2017-18201231839EQM140119; EQM210020SG-20-7257071515001220I10152; 22I10029ACT210096RED21993CW2680521R01 AG057234R01 AG083799Ibanez AParra MASlachevsky AForno GLillo PCerda MZitko PVillagra RThumala DfalseThe "when" matters: Evidence from memory markers in the clinical continuum of Alzheimer's disease.<h4>Objective</h4>Cognitive assessment able to detect impairments in the early neuropathological stages of Alzheimer's disease (AD) is urgently needed. The visual short-term memory binding task (VSTMBT) and the Free and Cued Selective Reminding Test (FCSRT) have been recommended by the neurodegenerative disease working group as promising tests to aid in the early detection of AD. In this study, we investigated their complementary value across the clinical stages of the AD continuum.<h4>Method</h4>One hundred and seventeen older adults with subjective cognitive complaint (SCC), 79 with mild cognitive impairment (MCI), 31 patients with AD dementia (ADD), and 37 cognitively unimpaired (CU) subjects, underwent assessment with the VSTMBT and the picture version of the Spanish FCSRT.<h4>Results<2023-01-01T00:00:00Z2023 Oct2025-04-18T14:06:08.134Z2025-04-07T00:02:52.574ZS-EPMC105227963722784510.1037/neu0000891