{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Schaeffer J"],"funding":["European Research Council"],"pagination":["2881-2898.e12"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10522804"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["111(18)"],"pubmed_abstract":["In the adult mammalian central nervous system (CNS), axons fail to regenerate spontaneously after injury because of a combination of extrinsic and intrinsic factors. Despite recent advances targeting the intrinsic regenerative properties of adult neurons, the molecular mechanisms underlying axon regeneration are not fully understood. Here, we uncover a regulatory mechanism that controls the expression of key proteins involved in regeneration at the translational level. Our results show that mRNA-specific translation is critical for promoting axon regeneration. Indeed, we demonstrate that specific ribosome-interacting proteins, such as the protein Huntingtin (HTT), selectively control the translation of a specific subset of mRNAs. Moreover, modulating the expression of these translationally"],"journal":["Neuron"],"pubmed_title":["Customization of the translational complex regulates mRNA-specific translation to control CNS regeneration."],"pmcid":["PMC10522804"],"funding_grant_id":["759089"],"pubmed_authors":["Diaz JJ","Nawabi H","Vilallongue N","Catez F","Schaeffer J","El Bakdouri N","Decourt C","Plissonnier E","Excoffier B","Saudou F","Blot B","Humbert S","Belin S","Paccard A"],"additional_accession":[]},"is_claimable":false,"name":"Customization of the translational complex regulates mRNA-specific translation to control CNS regeneration.","description":"In the adult mammalian central nervous system (CNS), axons fail to regenerate spontaneously after injury because of a combination of extrinsic and intrinsic factors. Despite recent advances targeting the intrinsic regenerative properties of adult neurons, the molecular mechanisms underlying axon regeneration are not fully understood. Here, we uncover a regulatory mechanism that controls the expression of key proteins involved in regeneration at the translational level. Our results show that mRNA-specific translation is critical for promoting axon regeneration. Indeed, we demonstrate that specific ribosome-interacting proteins, such as the protein Huntingtin (HTT), selectively control the translation of a specific subset of mRNAs. Moreover, modulating the expression of these translationally","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Sep","modification":"2026-05-29T02:05:19.25Z","creation":"2025-04-05T09:59:36.931Z"},"accession":"S-EPMC10522804","cross_references":{"pubmed":["37442131"],"doi":["10.1016/j.neuron.2023.06.005"]}}