{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Preeti"],"funding":["Council of Scientific and Industrial Research, India"],"pagination":["28434-28443"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10523091"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(41)"],"pubmed_abstract":["The manuscript focuses on a highly stereo-/regioselective approach for synthesizing a diverse array of substituted-3-hydroxy-2-oxindoles. The synthesized compounds were subsequently subjected to anti-proliferative assessment against various cell lines, including colorectal carcinoma, ovarian cancer, and human metastatic melanoma cancer. The structural characterization of the synthesized scaffolds was unambiguously confirmed using X-ray diffraction analysis. Among the synthesized compounds, one compound demonstrated exceptional potency within the series. It exhibited 1.2, 2.12, and 1.55 times greater potency than cisplatin against the HCT116, OVCAR10, and 1205Lu cell lines, respectively. These results were further supported by <i>in vitro</i> caspase-mediated apoptosis studies. Molecular do"],"journal":["RSC advances"],"pubmed_title":["Stereo/regio-selective access to substituted 3-hydroxy-oxindoles with anti-proliferative assessment and <i>in silico</i> validation."],"pmcid":["PMC10523091"],"funding_grant_id":["02(0400)/21/EMR-II"],"pubmed_authors":["Kumar V","Roussel P","Raza A","Henry N","Sharma AK","Preeti","Anand A"],"additional_accession":[]},"is_claimable":false,"name":"Stereo/regio-selective access to substituted 3-hydroxy-oxindoles with anti-proliferative assessment and <i>in silico</i> validation.","description":"The manuscript focuses on a highly stereo-/regioselective approach for synthesizing a diverse array of substituted-3-hydroxy-2-oxindoles. The synthesized compounds were subsequently subjected to anti-proliferative assessment against various cell lines, including colorectal carcinoma, ovarian cancer, and human metastatic melanoma cancer. The structural characterization of the synthesized scaffolds was unambiguously confirmed using X-ray diffraction analysis. Among the synthesized compounds, one compound demonstrated exceptional potency within the series. It exhibited 1.2, 2.12, and 1.55 times greater potency than cisplatin against the HCT116, OVCAR10, and 1205Lu cell lines, respectively. These results were further supported by <i>in vitro</i> caspase-mediated apoptosis studies. Molecular do","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Sep","modification":"2026-05-29T05:42:36.222Z","creation":"2025-02-19T00:10:33.869Z"},"accession":"S-EPMC10523091","cross_references":{"pubmed":["37771919"],"doi":["10.1039/d3ra05869g"]}}