biostudies-literatureUnknown24(1)Shen KAsthma is a common, chronic inflammatory disease of the airways that affects millions of people worldwide and is associated with significant healthcare costs. Eosinophils, a type of immune cell, play a critical role in the development and progression of asthma. Eosinophil extracellular traps (EETs) are reticular structures composed of DNA, histones, and granulins that eosinophils form and release into the extracellular space as part of the innate immune response. EETs have a protective effect by limiting the migration of pathogens and antimicrobial activity to a controlled range. However, chronic inflammation can lead to the overproduction of EETs, which can trigger and exacerbate allergic asthma. In this review, we examine the role of EETs in asthma.Respiratory research231https://www.ebi.ac.uk/biostudies/studies/S-EPMC10523707biostudies-literatureEosinophil extracellular traps in asthma: implications for pathogenesis and therapy.PMC10523707Shen KLi YLi CZhao RSun BZhang MLiu BLin JHou XXiang MfalseEosinophil extracellular traps in asthma: implications for pathogenesis and therapy.Asthma is a common, chronic inflammatory disease of the airways that affects millions of people worldwide and is associated with significant healthcare costs. Eosinophils, a type of immune cell, play a critical role in the development and progression of asthma. Eosinophil extracellular traps (EETs) are reticular structures composed of DNA, histones, and granulins that eosinophils form and release into the extracellular space as part of the innate immune response. EETs have a protective effect by limiting the migration of pathogens and antimicrobial activity to a controlled range. However, chronic inflammation can lead to the overproduction of EETs, which can trigger and exacerbate allergic asthma. In this review, we examine the role of EETs in asthma.2023-01-01T00:00:00Z2023 Sep2024-10-15T10:39:23.441Z2024-10-15T10:39:23.441ZS-EPMC105237073775251210.1186/s12931-023-02504-4