{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Azadian S"],"funding":["NIAID NIH HHS","Novo Nordisk Fonden","NIGMS NIH HHS"],"pagination":["2756-2764"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10524935"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["120(9)"],"pubmed_abstract":["Intercellular interactions and cell-cell communication are critical to regulating cell functions, especially in normal immune cells and immunotherapies. Ligand-receptor pairs mediating these cell-cell interactions can be identified using diverse experimental and computational approaches. Here, we reconstructed the intercellular interaction network between Mus musculus immune cells using publicly available receptor-ligand interaction databases and gene expression data from the immunological genome project. This reconstructed network accounts for 50,317 unique interactions between 16 cell types between 731 receptor-ligand pairs. Analysis of this network shows that cells of hematopoietic lineages use fewer communication pathways for interacting with each other, while nonhematopoietic stromal "],"journal":["Biotechnology and bioengineering"],"pubmed_title":["Reconstructing the cell-cell interaction network among mouse immune cells."],"pmcid":["PMC10524935"],"funding_grant_id":["UH2 AI153029","R35 GM119850","NNF21SA0066621"],"pubmed_authors":["Khodarahmi M","Zahiri J","Naseri M","Lewis NE","Yazdanifar M","Azadian S","Doustmohammadi A","Arab SS"],"additional_accession":[]},"is_claimable":false,"name":"Reconstructing the cell-cell interaction network among mouse immune cells.","description":"Intercellular interactions and cell-cell communication are critical to regulating cell functions, especially in normal immune cells and immunotherapies. Ligand-receptor pairs mediating these cell-cell interactions can be identified using diverse experimental and computational approaches. Here, we reconstructed the intercellular interaction network between Mus musculus immune cells using publicly available receptor-ligand interaction databases and gene expression data from the immunological genome project. This reconstructed network accounts for 50,317 unique interactions between 16 cell types between 731 receptor-ligand pairs. Analysis of this network shows that cells of hematopoietic lineages use fewer communication pathways for interacting with each other, while nonhematopoietic stromal ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Sep","modification":"2026-06-01T16:23:27.517Z","creation":"2025-04-06T13:47:31.298Z"},"accession":"S-EPMC10524935","cross_references":{"pubmed":["37227044"],"doi":["10.1002/bit.28431"]}}