biostudies-literatureAzadian SNIAID NIH HHSNovo Nordisk FondenNIGMS NIH HHS2756-2764https://www.ebi.ac.uk/biostudies/studies/S-EPMC10524935biostudies-literatureUnknown120(9)Intercellular interactions and cell-cell communication are critical to regulating cell functions, especially in normal immune cells and immunotherapies. Ligand-receptor pairs mediating these cell-cell interactions can be identified using diverse experimental and computational approaches. Here, we reconstructed the intercellular interaction network between Mus musculus immune cells using publicly available receptor-ligand interaction databases and gene expression data from the immunological genome project. This reconstructed network accounts for 50,317 unique interactions between 16 cell types between 731 receptor-ligand pairs. Analysis of this network shows that cells of hematopoietic lineages use fewer communication pathways for interacting with each other, while nonhematopoietic stromal Biotechnology and bioengineeringReconstructing the cell-cell interaction network among mouse immune cells.PMC10524935UH2 AI153029R35 GM119850NNF21SA0066621Khodarahmi MZahiri JNaseri MLewis NEYazdanifar MAzadian SDoustmohammadi AArab SSfalseReconstructing the cell-cell interaction network among mouse immune cells.Intercellular interactions and cell-cell communication are critical to regulating cell functions, especially in normal immune cells and immunotherapies. Ligand-receptor pairs mediating these cell-cell interactions can be identified using diverse experimental and computational approaches. Here, we reconstructed the intercellular interaction network between Mus musculus immune cells using publicly available receptor-ligand interaction databases and gene expression data from the immunological genome project. This reconstructed network accounts for 50,317 unique interactions between 16 cell types between 731 receptor-ligand pairs. Analysis of this network shows that cells of hematopoietic lineages use fewer communication pathways for interacting with each other, while nonhematopoietic stromal 2023-01-01T00:00:00Z2023 Sep2026-06-01T16:23:27.517Z2025-04-06T13:47:31.298ZS-EPMC105249353722704410.1002/bit.28431