biostudies-literatureAyalew SFIC NIH HHSMedical Research CouncilBiotechnology and Biological Sciences Research Council1204525https://www.ebi.ac.uk/biostudies/studies/S-EPMC10525399biostudies-literatureUnknown11<h4>Background</h4>Tuberculosis (TB) is a major cause of ill health and one of the leading causes of death worldwide, caused by species of the <i>Mycobacterium tuberculosis</i> complex (MTBC), with <i>Mycobacterium tuberculosis</i> being the dominant pathogen in humans and <i>Mycobacterium bovis</i> in cattle. Zoonotic transmission of TB (zTB) to humans is frequent particularly where TB prevalence is high in cattle. In this study, we explored the prevalence of zTB in central Ethiopia, an area highly affected by bovine TB (bTB) in cattle.<h4>Method</h4>A convenient sample of 385 patients with pulmonary tuberculosis (PTB, <i>N</i> = 287) and tuberculous lymphadenitis (TBLN, <i>N</i> = 98) were included in this cross-sectional study in central Ethiopia. Sputum and fine needle aspirate (FNA) sFrontiers in public healthZoonotic tuberculosis in a high bovine tuberculosis burden area of Ethiopia.PMC10525399D43 TW009127Zeleke METHICOBOTS ConsortiumVordermeier MAmeni GGebre STamiru MMohammed TMelese FYirga CAliy AHewinson RGMekonnen GHaile SGuta SWorku ATaye HMoore HLHailu TGari GWood JLNAseffa ATschopp RSolomon TAlmaw GTessema BMihret ASirak AOlani AHodge CAshford RTChanyalew MAyalew SConlan ABelachew BHabtamu GGemechu GNunez-Garcia JTerfassa LChothe SKZewude AMamo TTeklewold TBayissa BBekele ABerg SFekadu EAmbaw MWood JClarke AfalseZoonotic tuberculosis in a high bovine tuberculosis burden area of Ethiopia.<h4>Background</h4>Tuberculosis (TB) is a major cause of ill health and one of the leading causes of death worldwide, caused by species of the <i>Mycobacterium tuberculosis</i> complex (MTBC), with <i>Mycobacterium tuberculosis</i> being the dominant pathogen in humans and <i>Mycobacterium bovis</i> in cattle. Zoonotic transmission of TB (zTB) to humans is frequent particularly where TB prevalence is high in cattle. In this study, we explored the prevalence of zTB in central Ethiopia, an area highly affected by bovine TB (bTB) in cattle.<h4>Method</h4>A convenient sample of 385 patients with pulmonary tuberculosis (PTB, <i>N</i> = 287) and tuberculous lymphadenitis (TBLN, <i>N</i> = 98) were included in this cross-sectional study in central Ethiopia. Sputum and fine needle aspirate (FNA) s2023-01-01T00:00:00Z20232026-05-09T03:17:07.638Z2025-04-05T09:43:08.819ZS-EPMC105253993777183310.3389/fpubh.2023.1204525