{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhao J"],"funding":["Beijing Municipal Natural Science Foundation","Jiangxi National Science Foundation","Scientific Research Project of Beijing Youan Hospital，CCMU，2022","Beijing Municipal Institute of Public Medical Research Development and Reform Pilot Project","Capitals’s Funds for Health Improvement and Research","National Natural Science Foundation of China","Scientific Research Project of Beijing Youan Hospital, CCMU, 2022","the Beijing Municipal Institute of Public Medical Research Development and Reform Pilot Project"],"pagination":["2416"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10525902"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(9)"],"pubmed_abstract":["<h4>Background and aim</h4>Several studies have identified that three <i>SAMM50</i> polymorphisms (<i>rs2073082</i>, <i>rs738491</i>, <i>rs3761472</i>) are associated with an increased risk of non-alcoholic fatty liver disease (NAFLD). However, the clinical significance of the <i>SAMM50</i> SNP in relation to NAFLD remains largely unknown. Therefore, we conducted a clinical study and SNP-SNP interaction analysis to further elucidate the effect of the <i>SAMM50</i> SNP on the progression of NAFLD in the elderly.<h4>Methods</h4>A total of 1053 patients over the age of 65 years were recruited. Liver fat and fibrosis were detected by abdominal ultrasound or FibroScan, respectively. Genomic DNA was extracted and then genotyped by Fluidigm 96.96 Dynamic Array. Multivariable logistic regression w"],"journal":["Biomedicines"],"pubmed_title":["<i>SAMM50</i>-<i>rs2073082</i>, -<i>rs738491</i> and -<i>rs3761472</i> Interactions Enhancement of Susceptibility to Non-Alcoholic Fatty Liver Disease."],"pmcid":["PMC10525902"],"funding_grant_id":["BJYAYY-YN2022-17","82070627","7192084","2021-10","No.2020BABL206092","2020BABL206092","7222090","2022-2Z-2187"],"pubmed_authors":["Zhang J","Zhang Y","Wei X","Xu X","Zhang S","Xu H","Zhao J"],"additional_accession":[]},"is_claimable":false,"name":"<i>SAMM50</i>-<i>rs2073082</i>, -<i>rs738491</i> and -<i>rs3761472</i> Interactions Enhancement of Susceptibility to Non-Alcoholic Fatty Liver Disease.","description":"<h4>Background and aim</h4>Several studies have identified that three <i>SAMM50</i> polymorphisms (<i>rs2073082</i>, <i>rs738491</i>, <i>rs3761472</i>) are associated with an increased risk of non-alcoholic fatty liver disease (NAFLD). However, the clinical significance of the <i>SAMM50</i> SNP in relation to NAFLD remains largely unknown. Therefore, we conducted a clinical study and SNP-SNP interaction analysis to further elucidate the effect of the <i>SAMM50</i> SNP on the progression of NAFLD in the elderly.<h4>Methods</h4>A total of 1053 patients over the age of 65 years were recruited. Liver fat and fibrosis were detected by abdominal ultrasound or FibroScan, respectively. Genomic DNA was extracted and then genotyped by Fluidigm 96.96 Dynamic Array. Multivariable logistic regression w","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2026-05-13T14:23:54.561Z","creation":"2024-11-20T18:15:47.189Z"},"accession":"S-EPMC10525902","cross_references":{"pubmed":["37760857"],"doi":["10.3390/biomedicines11092416"]}}