biostudies-literaturePapini CSt. Baldrick&apos;s FoundationNational Cancer InstituteNCI NIH HHS3064-3075https://www.ebi.ac.uk/biostudies/studies/S-EPMC10528486biostudies-literatureUnknown129(19)<h4>Background</h4>Survivors of pediatric central nervous system (CNS) tumors are at risk for neurocognitive and social difficulties throughout childhood. This study characterized social cognition (perception and reasoning from social cues) and adjustment in adulthood.<h4>Methods</h4>A total of 81 adult survivors of pediatric CNS tumors (51% female; mean [SD] age, 28.0 [5.8] years), were recruited across four groups: (1) no radiation therapy (RT) [n = 21], (2) infratentorial (IT) tumors + focal RT [n = 20], (3) IT tumors + craniospinal irradiation [n = 20], and (4) supratentorial tumors + focal RT [n = 20]. Prevalence of social cognitive and adjustment impairments was compared to test norms. Multivariable models examined clinical and neurocognitive predictors of social cognition and its imCancerSocial cognition and adjustment in adult survivors of pediatric central nervous system tumors.PMC10528486P30 CA021765U01 CA195547Research Scholar AwardKrull KRWillard VWArmstrong GTSrivastava DBrinkman TMHudson MMGajjar AMerchant TEPapini CfalseSocial cognition and adjustment in adult survivors of pediatric central nervous system tumors.<h4>Background</h4>Survivors of pediatric central nervous system (CNS) tumors are at risk for neurocognitive and social difficulties throughout childhood. This study characterized social cognition (perception and reasoning from social cues) and adjustment in adulthood.<h4>Methods</h4>A total of 81 adult survivors of pediatric CNS tumors (51% female; mean [SD] age, 28.0 [5.8] years), were recruited across four groups: (1) no radiation therapy (RT) [n = 21], (2) infratentorial (IT) tumors + focal RT [n = 20], (3) IT tumors + craniospinal irradiation [n = 20], and (4) supratentorial tumors + focal RT [n = 20]. Prevalence of social cognitive and adjustment impairments was compared to test norms. Multivariable models examined clinical and neurocognitive predictors of social cognition and its im2023-01-01T00:00:00Z2023 Oct2025-04-04T01:03:17.346Z2025-04-04T01:03:17.346ZS-EPMC105284863732924510.1002/cncr.34889