biostudies-literatureAverina OVRussian Science FoundatioRussian Foundation for Basic ResearchRussian Science FoundationBulgarian National Science FundBulgarian Science Fund3356https://www.ebi.ac.uk/biostudies/studies/S-EPMC10530004biostudies-literatureUnknown12(18)<i>Bifidobacterium</i> is a predominant and important genus in the bacterial population of the human gut microbiota. Despite the increasing number of studies on the beneficial functionality of bifidobacteria for human health, knowledge about their antioxidant potential is still insufficient. Several in vivo and in vitro studies of <i>Bifidobacterium</i> strains and their cellular components have shown good antioxidant capacity that provided a certain protection of their own and the host's cells. Our work presents the data of transcriptomic, proteomic, and metabolomic analyses of the growing and stationary culture of the probiotic strain <i>B. longum</i> subsp. <i>longum</i> GT15 after exposure to hydrogen peroxide for 2 h and oxygen for 2 and 4 h. The results of the analysis of the sequencFoods (Basel, Switzerland)Oxidative Stress Response of Probiotic Strain <i>Bifidobacterium longum</i> subsp. <i>longum</i> GT15.PMC1053000420-54-1800620-14-00132-PКП-06-Русия/27KП-06-Pycия/2720-14-00132Danilenko VNMavletova DAKovtun ASKrastanov AAverina OVBlazheva DBrazkova MZiganshin RHSlavchev AIbrahim SAMihaylova DfalseOxidative Stress Response of Probiotic Strain <i>Bifidobacterium longum</i> subsp. <i>longum</i> GT15.<i>Bifidobacterium</i> is a predominant and important genus in the bacterial population of the human gut microbiota. Despite the increasing number of studies on the beneficial functionality of bifidobacteria for human health, knowledge about their antioxidant potential is still insufficient. Several in vivo and in vitro studies of <i>Bifidobacterium</i> strains and their cellular components have shown good antioxidant capacity that provided a certain protection of their own and the host's cells. Our work presents the data of transcriptomic, proteomic, and metabolomic analyses of the growing and stationary culture of the probiotic strain <i>B. longum</i> subsp. <i>longum</i> GT15 after exposure to hydrogen peroxide for 2 h and oxygen for 2 and 4 h. The results of the analysis of the sequenc2023-01-01T00:00:00Z2023 Sep2026-04-07T13:32:11.978Z2025-02-19T00:10:36.005ZS-EPMC105300043776106410.3390/foods12183356