{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hoffman SE"],"funding":["NCI NIH HHS","NIGMS NIH HHS"],"pagination":["eadd9668"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10530100"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(39)"],"pubmed_abstract":["Neuroendocrine tumors (NETs) are rare cancers that most often arise in the gastrointestinal tract and pancreas. The fundamental mechanisms driving gastroenteropancreatic (GEP)-NET growth remain incompletely elucidated; however, the heterogeneous clinical behavior of GEP-NETs suggests that both cellular lineage dynamics and tumor microenvironment influence tumor pathophysiology. Here, we investigated the single-cell transcriptomes of tumor and immune cells from patients with gastroenteropancreatic NETs. Malignant GEP-NET cells expressed genes and regulons associated with normal, gastrointestinal endocrine cell differentiation, and fate determination stages. Tumor and lymphoid compartments sparsely expressed immunosuppressive targets commonly investigated in clinical trials, such as the prog"],"journal":["Science advances"],"pubmed_title":["Intertumoral lineage diversity and immunosuppressive transcriptional programs in well-differentiated gastroenteropancreatic neuroendocrine tumors."],"pmcid":["PMC10530100"],"funding_grant_id":["R37 CA222574","R01 CA227388","T32 GM144273","T32 GM007753","T32 GM141745","U2C CA233195"],"pubmed_authors":["Wu J","Inga S","Sicinska E","Hornick JL","Dowrey TW","Bi K","Shannon E","Wang J","Napolitano S","DelloStritto L","Titchen B","Villacorta Martin C","Van Allen EM","Murphy GJ","Patel M","Rodig S","Yeung J","Park J","Chen J","Grimaldi G","Chan J","Johri S","Brais L","Hoffman SE","Besson NR","Kulke MH","Clancy T","Kao KZ","Huang Y","Mackichan C","Denning S","Wakiro I","Rotem A","Pfaff KL","Vigneau S"],"additional_accession":[]},"is_claimable":false,"name":"Intertumoral lineage diversity and immunosuppressive transcriptional programs in well-differentiated gastroenteropancreatic neuroendocrine tumors.","description":"Neuroendocrine tumors (NETs) are rare cancers that most often arise in the gastrointestinal tract and pancreas. The fundamental mechanisms driving gastroenteropancreatic (GEP)-NET growth remain incompletely elucidated; however, the heterogeneous clinical behavior of GEP-NETs suggests that both cellular lineage dynamics and tumor microenvironment influence tumor pathophysiology. Here, we investigated the single-cell transcriptomes of tumor and immune cells from patients with gastroenteropancreatic NETs. Malignant GEP-NET cells expressed genes and regulons associated with normal, gastrointestinal endocrine cell differentiation, and fate determination stages. Tumor and lymphoid compartments sparsely expressed immunosuppressive targets commonly investigated in clinical trials, such as the prog","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Sep","modification":"2026-06-04T12:29:52.361Z","creation":"2026-05-09T03:08:40.851Z"},"accession":"S-EPMC10530100","cross_references":{"pubmed":["37756410"],"doi":["10.1126/sciadv.add9668"]}}