biostudies-literatureCao Gthe National Key Research and Development Program of ChinaNational Natural Science Foundation of ChinaNational Key Research and Development Program of Chinathe National Natural Science Foundation of China13921https://www.ebi.ac.uk/biostudies/studies/S-EPMC10530892biostudies-literatureUnknown24(18)<i>FOXG1</i> (forkhead box G1) syndrome is a neurodevelopmental disorder caused by variants in the <i>Foxg1</i> gene that affect brain structure and function. Individuals affected by <i>FOXG1</i> syndrome frequently exhibit delayed myelination in neuroimaging studies, which may impair the rapid conduction of nerve impulses. To date, the specific effects of FOXG1 on oligodendrocyte lineage progression and myelination during early postnatal development remain unclear. Here, we investigated the effects of <i>Foxg1</i> deficiency on myelin development in the mouse brain by conditional deletion of <i>Foxg1</i> in neural progenitors using <i>NestinCreER;Foxg1^fl/fl</i> mice and tamoxifen induction at postnatal day 0 (P0). We found that <i>Foxg1</i> deficiency resulted in a transient deInternational journal of molecular sciencesConditional Deletion of <i>Foxg1</i> Delayed Myelination during Early Postnatal Brain Development.PMC105308922018YFF021520231200823Cao GLu HSun CShen CShen HQu DfalseConditional Deletion of <i>Foxg1</i> Delayed Myelination during Early Postnatal Brain Development.<i>FOXG1</i> (forkhead box G1) syndrome is a neurodevelopmental disorder caused by variants in the <i>Foxg1</i> gene that affect brain structure and function. Individuals affected by <i>FOXG1</i> syndrome frequently exhibit delayed myelination in neuroimaging studies, which may impair the rapid conduction of nerve impulses. To date, the specific effects of FOXG1 on oligodendrocyte lineage progression and myelination during early postnatal development remain unclear. Here, we investigated the effects of <i>Foxg1</i> deficiency on myelin development in the mouse brain by conditional deletion of <i>Foxg1</i> in neural progenitors using <i>NestinCreER;Foxg1^fl/fl</i> mice and tamoxifen induction at postnatal day 0 (P0). We found that <i>Foxg1</i> deficiency resulted in a transient de2023-01-01T00:00:00Z2023 Sep2025-06-25T03:04:20.652Z2025-04-05T09:43:18.052ZS-EPMC105308923776222010.3390/ijms241813921