{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["19"],"submitter":["Guo W"],"pubmed_abstract":["In this study, the effect of Douchi extract (<i>DWE</i>) on α-glucosidase and angiotensin-converting enzymes (ACE) were investigated, and several novel peptides with inhibitory activity against α-glucosidase and ACE were identified using peptidomics approach based on UPLC-MS/MS. The average inhibition rates of <i>DWE</i> on α-glucosidase and ACE were 73.75-78.10% and 4.56-27.07%, respectively. In the <i>DWE</i>, a total of 710 peptides were detected. Two novel peptides with potential inhibitory activity against α-glucosidase were identified using the correlation analysis, database alignment and molecular docking methods. They were DVFRAIPSEVL and DRPSINGLAGAN, with the IC<sub>50</sub> values of 0.121 and 0.128 mg/mL, respectively. Also, four novel peptides with potential inhibitory activit"],"journal":["Food chemistry: X"],"pagination":["100779"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10534093"],"repository":["biostudies-literature"],"pubmed_title":["Identification of novel α-glucosidase and ACE inhibitory peptides from Douchi using peptidomics approach and molecular docking."],"pmcid":["PMC10534093"],"pubmed_authors":["Lin Q","Jiang L","Ren K","Fu X","Long Z","Guo W","Xiao Y","Wu Y"],"additional_accession":[]},"is_claimable":false,"name":"Identification of novel α-glucosidase and ACE inhibitory peptides from Douchi using peptidomics approach and molecular docking.","description":"In this study, the effect of Douchi extract (<i>DWE</i>) on α-glucosidase and angiotensin-converting enzymes (ACE) were investigated, and several novel peptides with inhibitory activity against α-glucosidase and ACE were identified using peptidomics approach based on UPLC-MS/MS. The average inhibition rates of <i>DWE</i> on α-glucosidase and ACE were 73.75-78.10% and 4.56-27.07%, respectively. In the <i>DWE</i>, a total of 710 peptides were detected. Two novel peptides with potential inhibitory activity against α-glucosidase were identified using the correlation analysis, database alignment and molecular docking methods. They were DVFRAIPSEVL and DRPSINGLAGAN, with the IC<sub>50</sub> values of 0.121 and 0.128 mg/mL, respectively. Also, four novel peptides with potential inhibitory activit","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Oct","modification":"2026-04-29T02:30:48.306Z","creation":"2025-04-07T01:28:47.981Z"},"accession":"S-EPMC10534093","cross_references":{"pubmed":["37780236"],"doi":["10.1016/j.fochx.2023.100779"]}}