biostudies-literatureUnknown8(11)William J<h4>Importance</h4>Catheter ablation for patients with atrial fibrillation (AF) and heart failure with reduced ejection fraction (HFrEF) is associated with improved left ventricular ejection fraction (LVEF) and survival compared with medical therapy. Nonrandomized studies have reported improved success with posterior wall isolation (PWI).<h4>Objective</h4>To determine the impact of pulmonary vein isolation (PVI) with PWI vs PVI alone on outcomes in patients with HFrEF.<h4>Design, setting, and participants</h4>This was an ad hoc secondary analysis of the CAPLA trial, a multicenter, prospective, randomized control trial that involved 11 centers in 3 countries (Australia, Canada, and UK). CAPLA featured 338 patients with persistent AF randomized to either PVI plusPWI or PVI alone. This substuJAMA cardiology1077-1082https://www.ebi.ac.uk/biostudies/studies/S-EPMC10534992biostudies-literatureThe Role of Posterior Wall Isolation in Catheter Ablation for Persistent Atrial Fibrillation and Systolic Heart Failure: A Secondary Analysis of a Randomized Clinical Trial.PMC10534992McLellan AJPrabhu SLing LHSugumar HGinks MMorton JBSanders PVoskoboinik AAl-Kaisey ALee GPathak RKCrowley RReid CMWilliam JHawson JKalman JMSterns LChieng DSegan LWong MWong GKistler PMfalseThe Role of Posterior Wall Isolation in Catheter Ablation for Persistent Atrial Fibrillation and Systolic Heart Failure: A Secondary Analysis of a Randomized Clinical Trial.<h4>Importance</h4>Catheter ablation for patients with atrial fibrillation (AF) and heart failure with reduced ejection fraction (HFrEF) is associated with improved left ventricular ejection fraction (LVEF) and survival compared with medical therapy. Nonrandomized studies have reported improved success with posterior wall isolation (PWI).<h4>Objective</h4>To determine the impact of pulmonary vein isolation (PVI) with PWI vs PVI alone on outcomes in patients with HFrEF.<h4>Design, setting, and participants</h4>This was an ad hoc secondary analysis of the CAPLA trial, a multicenter, prospective, randomized control trial that involved 11 centers in 3 countries (Australia, Canada, and UK). CAPLA featured 338 patients with persistent AF randomized to either PVI plusPWI or PVI alone. This substu2023-01-01T00:00:00Z2023 Nov2025-04-04T01:03:09.734Z2025-04-04T01:03:09.734ZS-EPMC105349923775592010.1001/jamacardio.2023.3208