{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sayuti NH"],"funding":["Universiti Kebangsaan Malaysia"],"pagination":["6726"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10535396"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(18)"],"pubmed_abstract":["Neuronal models are an important tool in neuroscientific research. Hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), a major risk factor of neuronal oxidative stress, initiates a cascade of neuronal cell death. <i>Polygonum minus</i> Huds, known as 'kesum', is widely used in traditional medicine. <i>P. minus</i> has been reported to exhibit a few medicinal and pharmacological properties. The current study aimed to investigate the neuroprotective effects of <i>P. minus</i> ethanolic extract (PMEE) on H<sub>2</sub>O<sub>2</sub>-induced neurotoxicity in SH-SY5Y cells. LC-MS/MS revealed the presence of 28 metabolites in PMEE. Our study showed that the PMEE provided neuroprotection against H<sub>2</sub>O<sub>2</sub>-induced oxidative stress by activating the Nrf2/ARE, NF-κB/IκB and MAPK signaling"],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Ethanolic Extract of <i>Polygonum minus</i> Protects Differentiated Human Neuroblastoma Cells (SH-SY5Y) against H<sub>2</sub>O<sub>2</sub>-Induced Oxidative Stress."],"pmcid":["PMC10535396"],"funding_grant_id":["GGPM-2020-037"],"pubmed_authors":["Tan JK","Mukhtar S","Sarian MN","Parveen H","Sayuti NH","Baharum SN","Alsharif MA","Saad N","Hamezah HS","Bunawan H","Zulkefli N","Ahmed QU"],"additional_accession":[]},"is_claimable":false,"name":"Ethanolic Extract of <i>Polygonum minus</i> Protects Differentiated Human Neuroblastoma Cells (SH-SY5Y) against H<sub>2</sub>O<sub>2</sub>-Induced Oxidative Stress.","description":"Neuronal models are an important tool in neuroscientific research. Hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), a major risk factor of neuronal oxidative stress, initiates a cascade of neuronal cell death. <i>Polygonum minus</i> Huds, known as 'kesum', is widely used in traditional medicine. <i>P. minus</i> has been reported to exhibit a few medicinal and pharmacological properties. The current study aimed to investigate the neuroprotective effects of <i>P. minus</i> ethanolic extract (PMEE) on H<sub>2</sub>O<sub>2</sub>-induced neurotoxicity in SH-SY5Y cells. LC-MS/MS revealed the presence of 28 metabolites in PMEE. Our study showed that the PMEE provided neuroprotection against H<sub>2</sub>O<sub>2</sub>-induced oxidative stress by activating the Nrf2/ARE, NF-κB/IκB and MAPK signaling","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Sep","modification":"2025-04-04T13:32:29.674Z","creation":"2025-02-19T00:00:41.047Z"},"accession":"S-EPMC10535396","cross_references":{"pubmed":["37764502"],"doi":["10.3390/molecules28186726"]}}